探究疏肝健脾解郁汤治疗抑郁性失眠的临床疗效

Clinical Effect of Shugan Jianpi Jieyu Decoction on Depressive Insomnia

目的:探究疏肝健脾解郁汤治疗抑郁性失眠的临床疗效。方法:选取2017年12月至2018年12月福州市第一医院收治的抑郁性失眠患者162例,按照随机数字表法随机分为对照组和观察组,每组81例,对照组采用西药盐酸帕罗西汀片治疗,观察组采用疏肝健脾解郁汤治疗,比较2组治疗前后匹兹堡睡眠量表(PSQI)、汉密尔顿抑郁量表(HAMD)评分及血清P物质(SP)、5-羟色胺(5-HT)水平变化,评估治疗效果。结果:用药后观察组2组HAMD评分差异无统计学意义(P> 0. 05),但观察组PSQI评分及SP水平明显低于对照组,且5-HT水平及总有效率比较对照组明显更高(P <0. 05)。结论:疏肝健脾解郁汤可有效调节神经功能,改善抑郁状态,控制失眠症状,疗效显著。

Objective:To explore the clinical effect of Shugan Jianpi Jieyu Decoction in the treatment of depression and insomnia. Methods:From December 2017 to December 2018, 162 patients with depressive insomnia were randomly divided into two groups:control group(n=81)and observation group(n=81).The control group was treated with paroxetine hydrochloride tablets.The observation group was treated with Shugan Jianpi Jieyu decoction, and the changes of Pittsburgh sleep scale(PSQI), Hamilton depression scale(HAMD)score and serum substance P(SP), 5-hydroxytryptamine(5-HT)before and after treatment were compared between the two groups.Evaluate the effect of treatment. Results:There was no significant difference in the HAMD score between the two groups after treatment, but the PSQI score and SP level in the observation group were significantly lower than those in the control group, and the level of 5-HT and the total effective rate were significantly higher than those in the control group(P<0.05). Conclusion:Shugan Jianpi Jieyu Decoction can effectively adjust the function of the nerve, improve the state of depression, control the symptoms of insomnia, and has obvious curative effect.