酮替芬治疗Ⅱ型呼吸衰竭伴睡眠障碍的有效性和安全性

Efficacy and Safety of the Ketotifen Treatment on Patients with Ⅱ Type of Respiratory Failure and Sleep Disorders

目的:研究酮替芬对于Ⅱ型呼吸衰竭伴发睡眠障碍患者的作用与效果。方法:选取2015年12月至2018年11月德州市武城县四女寺镇卫生院收治的呼吸衰竭伴发睡眠障碍患者102例,随机分为对照组和观察组,每组51例,对照组采用安慰剂治疗,观察组在此基础上采用酮替芬治疗,观察比较2组结果。结果:观察组患者在治疗后其不良反应的发生率、匹茨堡睡眠质量指数(PSQI)评分都优于对照组患者,差异有统计学意义(P <0. 05)。结论:对于Ⅱ型呼吸衰竭伴发睡眠障碍患者来说,运用酮替芬可以促进其睡眠质量得到最大限度提升,临床推广价值较大。

Objective:To study the effect of ketotifen on patients with Ⅱ type respiratory failure and sleep disorders. Methods:102 cases of Ⅱ type of respiratory failure associated with sleep disorders in our hospital from December 2015 to November 2018 were enrolled.They were divided into control group and observation group,and each group included 51 cases.Control group received placebo treatment,while the observation group received ketotifen treatment based on placebo treatment;the results were compared and observed between the two groups. Results:The incidence of adverse reactions and Pittsburgh sleep quality index(PSQI)score of patients in observation group were better than that in the control group(P<0.05).Conclusions:For patients with Ⅱ type of respiratory failure associated with sleep disorders,using the ketotifen can promote the sleep quality of them to obtain the maximum enhancement.