系统评估X射线损伤修复交叉互补基因1多态性位点与冠心病相关性的Meta分析

Systematic evaluation of the association between XRCC1 polymorphisms and the risk of coronary artery disease:a meta-analysis

目的系统地评估X射线损伤修复交叉互补基因1(XRCC1)Arg399Gln和Arg194Trp多态性位点与冠状动脉粥样硬化性心脏病(coronary artery disease,CAD)易感性关联。方法检索PubMed、Google学术、万方和CNKI数据库,筛得XRCC1基因Arg399Gln和Arg194Trp多态性与CAD易感性关联的病例-对照研究。采用Stata 12.0数据计算软件对获得的各项研究数据进行分析统计,并对数据可靠性、发表偏倚等进行评估。结果纳入8项病例-对照研究,包含病例组3 093例,对照组2 799例。Meta分析结果提示,XRCC1基因Arg399Gln多态性位点与CAD易感性呈显著正相关(M比W:OR=1.153,95%CI:1.025～1.296,P=0.017;MM比WW:OR=1.514,95%CI:1.129～2.031,P=0.006;MM比MW+WW:OR=1.472,95%CI:1.110～1.953,P=0.007)。在以种族为依据的亚组分析中发现,XRCC1基因Arg399Gln多态性位点增加了亚洲人群CAD的发病风险。此外,研究还发现XRCC1基因Arg194Trp多态性位点在MM比WW和MM比MW+WW模型下与CAD发病风险呈显著正相关(MM比WW:OR=1.393,95%CI:1.048～1.850,P=0.022;MM比MW+WW:OR=1.499,95%CI:1.143～1.966,P=0.003)。在以种族为依据的亚组分析中,研究发现携带有XRCC1基因Arg194Trp多态性的亚洲人群易患CAD。结论 XRCC1基因Arg399Gln和Arg194Trp多态性位点与CAD易感性显著相关,可作为该疾病诊断和筛查的潜在靶点。

Objective To systematically evaluate the association between X-ray repair cross-complementing protein 1(XRCC 1)Arg399Gln and Arg194Trp polymorphisms and coronary artery disease(CAD)risk.Methods We retrieved the PubMed,Google Scholar,Wanfang and CNKI databases to search for all eligible case-control studies between XRCC 1 Arg399Gln and XRCC 1 Arg194Trp polymorphisms and CAD risk,adopted Stata 12.0 software to conduct all the calculations and evaluated the stability of the data and publication bias of the enrolled studies.Results Finally,a total of eight case-control studies were enrolled,including 3 093 cases and 2 799 controls.Meta-analysis results demonstrated that XRCC 1 Arg399Gln polymorphism was positively associated with an increased risk of CAD(M vs.W:OR=1.153,95%CI:1.025-1.296,P=0.017;MM vs.WW:OR=1.514,95%CI:1.129-2.031,P=0.006;MM vs.MW+WW:OR=1.472,95%CI:1.110-1.953,P=0.007).In addition,when the subgroup analysis was conducted based on ethnicity,we identified an increased risk of CAD in Asian population in allele contrast model.Besides,The XRCC 1 Arg194Trp polymorphism had significant positive association with the susceptibility to CAD under homozygote and recession models(MM vs.WW:OR=1.393,95%CI:1.048-1.850,P=0.022;MM vs.MW+WW:OR=1.499,95%CI:1.143-1.966,P=0.003).In the stratification analysis by ethnicity,we revealed that Asians carried with“M”allele of Arg194Trp polymorphism were significantly susceptible to CAD.Conclusion XRCC 1 Arg399Gln and Arg194Trp polymorphisms are significantly associated with the susceptibility to CAD,which can be regarded as potential biomarkers for the diagnosis and screening of CAD.