还原型谷胱甘肽对急性肾小球肾炎患儿血清IGF-Ⅱ,GM-CSF水平的影响

Effects of reduced glutathione on serum levels of IGF-Ⅱ and GM-CSF in children patients with acute glomerulonephritis

目的:探讨还原型谷胱甘肽(GSH)对急性肾小球肾炎患儿血清胰岛素生长因子Ⅱ(IGF-Ⅱ)、粒细胞-巨噬细胞集落刺激因子(GM-CSF)水平的影响。方法:选取某院接受治疗的136例急性肾小球肾炎患儿,按照随机数字法分为研究组与对照组各68例。对照组予以治疗急性肾小球肾炎常规药物(青霉素+速尿+硝苯地平),研究组在其基础上服用GSH进行治疗。比较2组患儿治疗前及治疗1周后血清生化指标(胰岛素样生长因子Ⅱ、粒细胞-巨噬细胞集落刺激因子)水平;记录2组患者治疗1周后临床疗效、临床症状(血压、尿量、水肿消退)恢复正常水平时间。结果:治疗1周后,2组患儿血清IGF-Ⅱ,GM-CSF水平均下降,且研究组明显低于对照组(P均<0.05);临床治疗总有效率研究组高于对照组(P<0.05);治疗期间,研究组患儿血压、尿量、水肿消退恢复时间均明显短于对照组,差异有统计学意义(P均<0.05)。结论:GSH用于治疗急性肾小球肾炎,可改善临床疗效,减少患儿炎性反应,促进患儿生长发育。

Objective :To investigate the effects of reduced glutathione (GSH) on serum levels of insulin growth factor II (IGF-II) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in children patients with acute glomerulonephritis. Methods :136 cases of children patients with acute glomerulonephritis treated in a hospital were selected and randomly divided into a study group and a control group, with 68 cases in each.The control group was treated with conventional drugs (penicillin+ furosemidum+ nifedipine), and the study group was given GSH on this basis.Serum biochemical parameters (IGF-II and GM-CSF levels) were compared between the two groups before treatment and one week after the treatment.Clinical efficacy (evaluation criteria of efficacy of glomerulonephritis) and the time of normal recovery of clinical symptoms (blood pressure, urine volume, and edema extinction) were recorded in the two groups one week after the treatment. Results :One week after the treatment, serum IGF-II and GM-CSF levels in the two groups were decreased, and the levels in the study group were significantly lower than those in the control group (both P<0.05).The total effective rate of clinical treatment in the study group was significantly higher than that in the control group(P<0.05).During the treatment, the recovery time of blood pressure, urine volume and edema extinction in the study group were significantly shorter than that in the control group (all P<0.05). Conclusion: GSH for acute glomerulonephritis can improve clinical efficacy, reduce the inflammatory response and promote the growth and development of children patients.