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蛋白C/蛋白S缺乏肺血栓栓塞症中血小板聚集功能的研究进展 被引量:8

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摘要 肺血栓栓塞症(Pulmonary thromboembolism,PTE)是来自静脉系统或右心的血栓阻塞肺动脉或其分支、以呼吸功能和肺循环障碍为表现的疾病,其发病及临床症状呈多样性表现,发病率以及病死率均较高[1],据报道,美国每年有超过29万的PTE患者,其中约1/3的患者死亡[2]。
出处 《临床肺科杂志》 2019年第4期751-754,共4页 Journal of Clinical Pulmonary Medicine
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  • 1Liu HW,Kwong YL,Bourke C,et al.High incidence of thrombophilia detected in Chinese patients with venous thrombosis.Thromb Haemost,1994,71:416-419.
  • 2Shen MC,Lin JS,Tsay W.High prevalence of antithrombin Ⅲ,protein C and protein S deficiency,but no factor V Leiden mutation in venous thrombophilic Chinese patients in Taiwan.Thromb Res,1997,87:377-385.
  • 3Seligsohn U,Lubetsky A.Genetic susceptibility to venous thrombosis.N Engl J Med,2001,344:1222-1231.
  • 4Tait RC,Walker ID,Reitsma PH,et al.Prevalence of protein C deficiency in the healthy population.Thromb Haemost,1995,73:87-93.
  • 5Tait RC,Walker ID,Perry DJ,et al.Prevalence of antithrombin deficiency in the healthy population.Br J Haematol,1994,87:106-112.
  • 6Dykes AC,Walker ID,McMahon AD,et al.A study of protein S antigen levels in 3788 healthy volunteers:influence of age,sex and hormone use,and estimate for prevalence of deficiency state.Br J Haematol,2001,113:636-641.
  • 7Beauchamp NJ,Dykes AC,Parikh N,et al.The prevalence of,and molecular defects underlying,inherited protein S deficiency in the general population.Br J Haematol,2004,125:647-654.
  • 8Wells PS,Blajchman MA,Henderson P,et al.Prevalence of antithrombin deficiency in healthy blood donors:a cross-sectional study.Am J Hematol,1994,45:321-324.
  • 9Henkens CM,Bom VJ,van der Schaaf W,et al.Plasma levels of protein S,protein C,and factor X:effects of sex,hormonal state and age.Thromb Haemost,1995,74:1271-1275.
  • 10Liberti G,Bertina RM,Rosendaal FR. Hormonal state rather than age influences cut-off values of protein S:reevaluation of the thrombotic risk associated with protein S deficiency. Thromb Haemost,1999,82:1093-1096.

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