小檗碱对大鼠口服阿托伐他汀钙药代动力学的影响

Effects of berberine on the pharmacokinetics of atorvastatin calcium by gavage in rats

目的研究小檗碱对大鼠口服阿托伐他汀钙药代动力学的影响,为临床联合用药提供参考依据。方法大鼠随机分为5组,单次阿托伐他汀钙组(A组)、单次小剂量小檗碱+阿托伐他汀钙组(B组)、单次大剂量小檗碱+阿托伐他汀钙组(C组)、多次小剂量小檗碱+单次阿托伐他汀钙组(D组)及多次大剂量小檗碱+单次阿托伐他汀钙组(E组)。给药前后眼眶采血,采用HPLC法测定大鼠体内阿托伐他汀钙的浓度。经DAS 2.0药动学软件处理,获得各组药动学参数。结果大鼠在单次及多次灌胃不同剂量的小檗碱后,阿托伐他汀钙的体内药代动力学参数改变无统计学意义。结论正常用量下小檗碱对大鼠阿托伐他汀钙的药代动力学有一定的影响,但无统计学意义,在人体内的影响仍需进一步研究。

Objective To study the effect of berberine on the pharmacokinetics of atorvastatin calcium in rats,and provide a reference for the combination use of berberine and atorvastatin calcium.Methods Rats were randomly divided into 5 groups:group A was treated with single atorvastatin calcium,group B was treated with single low-dose berberine+atorvastatin calcium,group C with single high-dose berberine+atorvastatin calcium,group D with multiple low-dose berberine+single atorvastatin calcium,group E with multiple high-dose berberine+single atorvastatin calcium.Blood was collected from the eyelids before and after administration,and the concentration of atorvastatin calcium in rats was determined by HPLC.The data was processed by DAS 2.0 pharmacokinetic software to obtain pharmacokinetic parameters for each group.Results The pharmacokinetic parameters of atorvastatin calcium had no statistically significant change after single and multiple different doses of berberine by gavage in rats.Conclusion Berberine at normal dose has a certain effect on the pharmacokinetics of atorvastatin calcium in rats but there's no statistical significance,further research is needed in humans.