结核性胸膜炎患者应用地塞米松治疗的疗效分析

Therapeutic Effect of Dexamethasone in Patients with Tuberculous Pleurisy

目的探讨分析结核性胸膜炎患者应用地塞米松治疗的临床效果。方法选取该院自2016年3月—2017年3月收治的结核性胸膜炎患者80例为该次研究对象,随机分为对照组和观察组,每组40例患者。对对照组结核性胸膜炎患者进行常规化疗以及抽胸液治疗。观察组结核性胸膜炎患者在对照组的基础上添加地塞米松注射治疗。观察两组结核性胸膜炎患者在治疗后的治疗效果,比较两组患者的胸液抽取时间和胸液抽取次数,血沉恢复正常时间,临床病症消除时间以及总体住院治疗时间。结果对照组结核性胸膜炎患者的胸液抽取时间(13.4±2.1)h,胸液抽取次数4次与观察组结核性胸膜炎患者的胸液抽取时间(13.5±2.1)h,胸液抽取次数4次比较差异不明显,数据比较差异无统计学意义(t=1.092,χ~2=2.758,P>0.05)。观察组结核性胸膜炎患者的血沉恢复正常时间(14.67±1.34)d,临床病症消除时间[发热消除时间(4.57±0.23)d,胸痛消除时间(7.34±0.23)d],干咳消除时间(7.34±0.67)d,气短消除时间(6.98±0.34)d以及总体住院治疗时间(52.32±3.27)d均低于对照组结核性胸膜炎患者的血沉恢复正常时间(19.56±1.08)d,临床病症消除时间发热消除时间(7.34±0.29)d,胸痛消除时间(2.56±0.21)d,干咳消除时间(12.23±0.75)d,气短消除时间(10.45±0.63)d以及总体住院治疗时间(68.39±5.67)d,两组数据比较差异有统计学意义(t=2.567,2.156,2.987,3.234,3.458,5.896,P<0.05)。结论应用地塞米松治疗结核性胸膜炎患者临床效果显著,能够迅速有效的消除患者临床症状,及时恢复患者的正常血沉,并且减少患者的住院时间,能够节省医疗资源,减少经济负担,应用价值高,值得医院临床推荐。

Objective To investigate the clinical effect of dexamethasone in patients with tuberculous pleurisy.Methods Eighty patients with tuberculous pleurisy admitted to our hospital from March 2016 to March 2017 were enrolled in this study.They were randomly divided into control group and observation group,with 40 patients in each group.Patients in the control group with tuberculous pleurisy were treated with conventional chemotherapy and pleural effusion.In the observation group,patients with tuberculous pleurisy were treated with dexamethasone injection on the basis of the control group.The therapeutic effects of patients with tuberculous pleurisy after treatment were observed.The pleural fluid extraction time and pleural fluid extraction times,erythrocyte sedimentation rate recovery time,clinical disease elimination time and overall hospitalization time were compared between the two groups.Results The pleural fluid extraction time of patients with tuberculous pleurisy in the control group was(13.4±2.1)h,the number of pleural fluid extractions was 4 times,and the pleural fluid extraction time of patients with tuberculous pleurisy in the observation group was(13.5±2.1)h,and the number of pleural fluid extractions was not significantly different.There was no significant difference in data comparison(t=1.092,χ^2=2.758,P>0.05).The erythrocyte sedimentation rate in patients with tuberculous pleurisy returned to normal time(14.67±1.34)d,the time of clinical disease elimination(heating elimination time(4.57±0.23)d,chest pain elimination time(7.34±0.23)d,dry cough elimination time(7.34±0.67)d,air short elimination time(6.98±0.34)d and overall hospitalization time(52.32±3.27)d was lower than the normal time of erythrocyte sedimentation rate in patients with tuberculous pleurisy in the control group(19.56±1.08)d,the time of clinical disease elimination(heating elimination time(7.34±0.29)d,chest pain elimination time(12.56±0.21)d,dry cough elimination time(12.23±0.75)d,air short elimination time(10.45±0.63)d and overall hospitalization time(68.39±5.67)d.The difference between the two groups was statistically significant(t=2.567,2.156,2.987,3.234,3.458,5.896,P<0.05).Conclusion The clinical effect of dexamethasone in the treatment of tuberculous pleurisy is significant.It can quickly and effectively eliminate the clinical symptoms of patients,restore the normal erythrocyte sedimentation rate in time,reduce the hospitalization time of patients,save medical resources,reduce economic burden,and have high application value.It is worthy of hospital clinical recommendation.