580例质子泵抑制剂预防应激性溃疡(SU)用药分析

Analysis of 580 Proton Pump Inhibitors for Prevention of Stress Ulcer(SU)

目的了解该院重点临床科室质子泵抑制剂(PPI)预防应激性溃疡(SU)的使用情况,为临床合理用药提供参考。方法抽取该院2017年4—10月PPI预防应激性溃疡使用排名前8位的临床科室出院患者病历共580份,对其PPI使用合理性进行专项点评和分析。结果 580份病历中,324份使用不合理(占55.86%),包括无指征用药的163份(占50.431%),用药剂量不适宜的92份(占28.39%),用药疗程不合理的42份(占12.96%),溶谋选择不适宜的27份(占8.33%)。质子泵抑制剂(PPI)中以泮托拉唑使用频次最高,使用率为PPI制剂的69.33%。结论该院PPI预防应激性溃疡(SU)不合理使用率较高,存在过度使用或滥用的情况,应采取监控措施规范PPI预防应激性溃疡的使用,促进临床合理用药。

Objective To understand the use of proton pump inhibitor(PPI)in the main clinical department of our hospital to prevent the use of stress ulcer(SU),and to provide reference for clinical rational drug use.Methods A total of 580 medical records were collected from the top 8 clinical departments of PPI to prevent stress ulcers from April to October 2017 in our hospital.Special evaluation and analysis were made on the rationality of PPI use.Results Of the 580 medical records,324 were unreasonable(55.86%),including 163(50.31%)without indications,and 92(28.39%)with unsuitable doses.The treatment was unreasonable.of the 42(accounting for 12.96%),27 were unsuitable for the selection of the solution(accounting for 8.33%).The proton pump inhibitor(PPI)has the highest frequency of pantoprazole and the use rate was 69.33% of the PPI preparation.Conclusion PPI in our hospital can prevent the unreasonable use rate of stress ulcer(SU).If there is excessive use or abuse,we should adopt monitoring measures to regulate the use of PPI to prevent stress ulcers and promote clinical rational drug use.