乳果糖联合双歧杆菌三联活菌肠溶胶囊对肝硬化SBP患者疗效观察

Observation on the Efficacy of Lactulose Combined With Bifid Triple Viable Capsules Dissolving at Intestines in Patients With Liver Cirrhosis and Spontaneous Bacterial Peritonitis

目的探讨乳果糖联合金双歧对肝硬化自发性细菌性腹膜炎(spontaneous bacterial peritonitis,SBP)患者的疗效。方法将2016年8月—2017年12月在武威肿瘤医院肝胆中心就诊的肝硬化SBP患者随机分为治疗组和对照组,治疗组在SBP治愈后,常规给予乳果糖10mL/次,3次/日,联合金双歧2粒/次,3次/日口服,对照组在SBP治愈后不再给予药物干预。3个月后比较两组患者SBP再发生率和血氨水平。结果治疗结束3个月后治疗组与对照组相比腹膜炎再发生率下降,差异有统计学意义(8.57%vs. 28.12%,P <0.05),血氨水平下降,差异有统计学意义(P <0.05)。结论乳果糖联合双歧杆菌乳杆菌三联活菌片可降低肝硬化SBP患者的复发率,可降低患者血氨水平。

Objective To explore the curative effect of lactulose and Gold dichotomous in patients with liver cirrhosis and spontaneous bacterial peritonitis (SBP). Methords Patients of liver cirrhosis and SBP were devided into the treatment group and the control group in hepatobiliary disease center from August 2016 to December 2017. After SBP was cured, the treatment group was treated by lactulose 10 mL every time, 3 times a day combined with Gold dichotomous, 2 pills every time,3 times a day. The control group was given nothing. After 3 months,the recurrence rate of SBP and the level of blood ammonia were compared. Result The recurrence rate of SBP (8.57%vs28.12%, P < 0.05) and the level of blood ammonia (P < 0.05) were all decreased in the treatment group compared to the control group (P < 0.05). These difference were statistically significant. Conclusion SBP patients were treated by lactulose and Gold dichotomous can reduce the recurrence rate of SBP and the level of blood ammonia.