硫普罗宁联合拉米夫定治疗肺结核合并慢性乙型肝炎的效果及其对肝功能、T淋巴细胞免疫应答的影响

Effect of tiopronin combined with lamivudine in the treatment of tuberculosis complicated with chronic hepatitis B and its influence on liver function and T lymphocyte immune response

目的探讨硫普罗宁联合拉米夫定(LAM)治疗肺结核合并慢性乙型肝炎(CHB)的效果及其对肝功能、T淋巴细胞免疫应答的影响。方法将106例肺结核合并CHB患者随机分为对照组(LAM治疗)和观察组(硫普罗宁+LAM治疗),每组53例。比较两组的治疗效果、肝功能、细胞免疫功能及不良反应发生情况。结果观察组愈显率、治疗总有效率、ALT、AST、TBIL、CD4+、CD8+水平及CD4^+/CD8^+均显著优于对照组(P<0.05)。结论肺结核合并CHB治疗中应用硫普罗宁联合LAM,有助于改善患者的肝功能及免疫功能,提高临床疗效。

Objective To investigate the effect of tiopronin combined with lamivudine(LAM) on tuberculosis complicated with chronic hepatitis B(CHB) and its influence on liver function and T lymphocyte immune response. Methods A total of106 patients with tuberculosis complicated with CHB were randomly divided into control group(LAM therapy) and observation group(tiopronin +LAM therapy), with 53 cases in each group. The therapeutic effects, liver function, cellular immune function and adverse reactions were compared between the two groups. Results The markedly effective rate, total therapeutic efficiency, ALT, AST, TBIL, CD4^+, CD8^+levels and CD4^+/CD8^+in the observation group were significantly better than those in the control group(P<0.05). Conclusion Tiopronin combined with LAM in the treatment of pulmonary tuberculosis complicated with CHB can help improve the liver function, immune function of patients and improve the clinical efficacy.