胃肠胰神经内分泌肿瘤的治疗进展

Treatment progress of gastroenteropancreatic neuroendocrine neoplasms

总结胃肠胰神经内分泌肿瘤(GEP-NENs)的治疗进展,为临床治疗GEP-NENs提供参考依据。通过查阅国内外相关文献,对GEP-NENs的治疗进展进行总结。随着内镜的使用及筛查技术的提高,GEP-NENs的检出率逐渐升高,临床医师有必要对其治疗方法有所掌握。早期肿瘤可通过内镜及手术治疗达到治愈的效果,晚期肿瘤可通过全身化疗、靶向治疗(依维莫司、舒尼替尼)、放射性核素治疗等手段延缓肿瘤发展、抑制肿瘤增殖以延长生命。目前虽然该疾病得到重视,治疗水平有所提高,但仍有很多难题,探索的步伐不曾停止。

To summarize the treatment progress of gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs), and to provide references for clinical treatment of GEP-NENs. By consulting the relevant literatures at our country and abroad, the treatment progress of GEP-NENs was summarized. With the use of endoscopy and the improvement of screening technology,the detection rate of GEP-NENs gradually increase. It is necessary for clinicians to master the treatment methods of GEPNENs. Early neoplasms can be cured by endoscopy and surgical treatment. Survival time of patients with advanced neoplasms can be prolonged by systemic chemotherapy, targeted therapy(everolimus, sunitinib), radionuclide therapy and other means to delay the development of neoplasms and inhibit the proliferation of neoplasms. Although attention has been paid to the disease and the level of treatment has been improved, there are still many problems and the pace of exploration has not stopped.