健力怡神膏固体化工艺研究

Research on the Process of Converting Jianli Yishen from Semi-fluid to Solid

目的建立健力怡神膏固体化的工艺,为实现健力怡神膏的形态由半流体转变为固体提供方法。方法按L_9(3~3)三因素三水平正交试验表设计实验,以成品外观性状、辅料添加量、口尝甜度和有效成分含量为考察指标,权重分别为0.3、0.1、0.1、0.5,综合评分结果采用SPSS 21.0统计软件进行数据分析。结果优选出的辅料最佳配比为阿胶∶冰糖∶红枣粉=0.75∶0.5∶1。各因素对综合评分影响程度为红枣粉>阿胶>冰糖,其中红枣粉、阿胶具有显著性差异(P<0.05)。结论以优选出的辅料配比制备的健力怡神膏呈固体块状,携带方便、稳定性高、分剂量准确,可在临床推广应用。

OBJECTIVE To establish a solidification process for Jianli Yishen Paste and to provide a method for converting the shape of Jianli Yishen Paste from a semi-fluid to a solid. METHODS Experimental designed according to the L 9(3 3) three-factor three-level orthogonal test table,taking the appearance characteristics,the amount of excipients,the sweetness and the content of active ingredients as inspection indicators,weights were 0.3,0.1,0.1,and 0.5 respectively,and the overall scores were analyzed by SPSS 21.0 statistical software. RESULTS The best matching ratio of excipients was donkey-hide gelatin∶ rock sugar∶ jujube powder=0.75∶ 0.5∶ 1.The influence of each factor on the comprehensive score was jujube powder>donkey-hide gelatin>rock candy,among which jujube powder and donkey-hide gelatin had significant differences ( P <0.05). CONCLUSION The Jianli Yishen solids prepared with the preferred excipient ratios are solid blocks,which are convenient to carry,high in stability,accurate in dosage,and can be popularized and applied in clinical practice.