卵巢癌合并2型糖尿病发生的危险因素分析

Analysis of Risk Factors for Ovarian Cancer Complicated with Type 2 Diabetes

目的研究卵巢癌合并2型糖尿病的危险因素。方法选择2010年1月～2017年12月我院住院病历中出院诊断为卵巢癌合并2型糖尿病,经病理确诊的21例患者设病例组,另选择未合并糖尿病的卵巢癌患者47例设为对照组,收集患者临床资料,包括一般情况、生育史、月经史、避孕史、家族史和既往史等,并采用非条件Logistic回归分析。结果单因素分析显示,高血压、盆腔囊肿和高脂血症等是卵巢癌合并2型糖尿病的危险因素。多因素分析显示与卵巢癌合并2型糖尿病发生显著关联的是盆腔囊肿和高脂血症,OR值分别为8.536(95%CI 1.386～52.556)、5.346(95%CI,1.069～26.738)。结论卵巢癌合并2型糖尿病的发生发展受多种因素相互作用的影响。积极治疗盆腔囊肿和高脂血症,可预防和控制卵巢癌合并2型糖尿病的发生发展。

Objective To study the risk factors of ovarian cancer with type 2 diabetes. Methods From January 2010 to December 2017,21 patients were diagnosed with ovarian cancer complicated with type 2 diabetes as case group, 47 patients were diagnosed with ovarian cancer without type 2 diabetes as control group.The clinical data of the patients were collected, including general condition, birth history, menstrual history, contraceptive history, family history and past history, and unconditional logistic regression analysis was used. Results Univariate analysis showed that hypertension, pelvic cysts and hyperlipidemia were risk factors for ovarian cancer with type 2 diabetes. Multivariate analysis showed that ovarian cancer with type 2 diabetes was significantly associated with pelvic cysts and hyperlipidemia, with OR values of 8.536 (95% CI 1.386 to 52.556) and 5.346 (95% CI, 1.069 to 26.738), respectively. Conclusion The occurrence and development of ovarian cancer with type 2 diabetes is affected by the interaction of various factors. Active treatment of pelvic cysts and hyperlipidemia can prevent and control the occurrence and development of ovarian cancer with type 2 diabetes.