介入栓塞联合射频消融治疗肝巨大局灶性结节性增生的疗效评价

Efficacy evaluation of interventional embolization combined with radiofrequency ablation for massive focal nodular hyperplasia of the liver

目的探讨介入栓塞联合射频消融治疗肝巨大局灶性结节性增生患者的临床疗效。方法选择2014年1月至2016年1月期间本院收治的肝巨大局灶性结节性增生患者56例作为资料进行研究,依据瘤体大小分组,瘤体直径<10 cm为对照组(28例),瘤体直径≥10 cm为观察组(28例),均行介入栓塞联合射频消融治疗,观察介入栓塞和射频消融效果,随访两年观察复发情况、并发症等。结果观察组与对照组介入栓塞效果、射频消融效果及术后复发情况比较,差异无统计学意义;观察组射频消融时间显著长于对照组(P<0.05);两组术后住院时间比较差异无统计学意义;观察组并发症发生率17.86%与对照组10.71%比较差异有统计学意义(P<0.05)。结论针对肝巨大局灶性结节性增生采用介入栓塞联合射频消融治疗可获得良好的介入栓塞效果和射频消融效果,确保填充完全,促使瘤体缩小,且可控制并发症和复发情况,保证治疗安全性和彻底性,值得推广应用。

Objective To investigate the clinical efficacy of interventional embolization combined with radiofrequency ablation in the treatment of massive focal nodular hyperplasia of the liver. Methods From January 2014 to January 2016, 56 patients with massive hepatic nodular hyperplasia admitted to our hospital were selected as the data. The tumor size was grouped according to the tumor size, and the tumor diameter was <10 cm (28 cases), the diameter of the tumor was ≥10 cm for the observation group (28 cases). All patients underwent interventional embolization combined with radiofrequency ablation. The effects of interventional embolization and radiofrequency ablation were observed. The recurrence and complications were observed after 2 years of follow-up. Results There was no significant difference in the interventional embolization effect, radiofrequency ablation effect and postoperative recurrence between the observation group and the control group. The radiofrequency ablation time of the observation group was significantly longer than that of the control group (P<0.05). There was no difference in postoperative hospital stay between the two groups. The incidence of complications in the observation group was 17.86% compared with 10.71% in the control group (P<0.05). Conclusion Interventional embolization combined with radiofrequency ablation for large hepatic focal nodular hyperplasia can achieve good interventional embolization and radiofrequency ablation, ensure complete filling, promote tumor shrinkage, and control complications and recurrence to ensure treatment. Safety and thoroughness are worth promoting.