心脉隆注射液对肺心病并发难治性心力衰竭患者和肽素的影响

Effects of Xinmailong injection on patients with pulmonary heart disease complicated by refractory heart failure and Copeptin

目的研究心脉隆注射液治疗慢性肺源性心脏病并发难治性心力衰竭患者的临床疗效及对和肽素的影响。方法选择2014年12月至2018年1月收治的慢性肺源性心脏病并发难治性心力衰竭患者82例,随机分为治疗组和对照组,每组41例。对照组给予常规治疗,治疗组在对照组基础上加用心脉隆注射液静脉滴注,连续应用12 d。观察2组患者的临床疗效及6 min步行距离(6-MWT);2组患者治疗前后肺动脉收缩压(PASP)、肺动脉平均压(MPAP)、左心室射血分数(LVEF);检测2组治疗前后NT-proBNP以及和肽素水平。结果治疗组总有效率为92.68%明显高于对照组的78.05%,差异有统计学意义(P<0.05)。治疗前,2组患者肺动脉压、NT-proBNP、和肽素及6-MWT差异均无统计学意义(P>0.05)。治疗后12 d,2组肺动脉压、NT-proBNP、和肽素及6-MWT均有不同程度的改善,治疗组改善程度更加显著(P<0.05)。相关分析显示和肽素与患者病情程度呈正相关关系(r=0.806,P<0.01),即和肽素水平越高,患者病情越重。结论心脉隆能有效改善患者心功能,降低和肽素水平,迅速缓解临床症状,治疗效果显著。

Objective To observe the clinical curative effects of Xinmailong injection on chronic pulmonary heart disease complicated by refractory heart failure and its effects on Copeptin.Methods A total of 82 patients with chronic pulmonary heart disease complicated by refractory heart failure who were admitted and treated in our hospital from December 2014 to January 2018 were randomly divided into treatment group(n=41)and control group(n=41).The patients in control group were given routine therapy,however,the patients in treatment group,on the basis of control group,were treated by intravenous drip of Xinmailong injection for 12 days.The clinical curative effects and 6-minute walking distance were observed.Moreover the pulmonary artery systolic pressure(PASP),mean pulmonary artery pressure(MPAPP),left ventricular ejection fraction(LVEFV),and the levels of NT-proBNP and peptide were detected before and after treatment.Results The total effective rate in treatment group was significantly higher than that in control group(P<0.05).Before treatment,there were no significant differences in pulmonary arterial pressure,NT-proBNPP,Copeptin and 6-MWT between the two groups(P>0.05).At 12 days after treatment,the pulmonary arterial pressure,NT-proBNPP,Copeptin peptide and 6-MWT were improved in both groups to some extent,moreover,the improvement degree in treatment group was more significant than that in control group(P<0.05).Correlation analysis showed that the higher the levels of Copeptin,the more severe the patient’s disease condition,there was a positive correlation between them(r=0.806,P<0.01).Conclusion Xinmailong can effectively improve the heart function of patients with chronic pulmonary heart disease complicated by refractory heart failure,which can reduce the levels of Copeptin and relieve clinical symptoms quickly,with obvious therapeutic effects.