肺浸润性腺癌组织中去泛素化酶USP17与基质金属蛋白-9的表达研究

Expression and significance of USP17 and MMP-9 in lung invasive adenocarcinoma

目的 :检测肺浸润性腺癌术后组织中去泛素化酶USP17(USP17)和基质金属蛋白酶-9(MMP-9)的表达特征,分析其在临床病理特征中的表达差别,探讨二者的相关性,关注对判断预后的价值。方法:本实验以75例肺浸润性腺癌作为观察组,以32例正常肺组织作为对照组,应用免疫组化方法检测二组中USP17和MMP-9的表达。结果:二组中USP17和MMP-9的表达差别有统计学意义,观察组中二者的表达与癌栓、分化及淋巴结转移有关,USP17的表达与Ki67指数和最大径有关。相关分析显示观察组中USP17和MMP-9的表达具有正相关性。二者表达与预后有关。结论:USP17和MMP-9在肺浸润性腺癌术后组织高表达,具有相关性,对病变的进展有一定调节作用,联合检测二者可能对判断预后有一定价值。

Objective: To detect the expression of USP17 and MMP-9 in lung invasive adenocarcinoma, investigate their relationship, prognostic significance. Methods: The study included 75 lung invasive adenocarcinoma as observation group, 32 normal lung tissue as control group. Expressions of USP17 and MMP-9 were detected by IHC methods in two groups. Results: The positive rate of USP17 and MMP-9 was obvious different in two groups. Expressions of USP17 and MMP-9 were closely related to vascular involvement, differentiation and lymph node metastasis. Expression of USP 17 was closely related to proliferation index and maximum diameter. There was positive correlation between USP17 and MMP-9 in observation group. Expressions of ID-2 and VEGF-D were closely related to survival time in observation group. Conclusions: Higher expressions and positive relationship of USP17 and MMP-9 may promote the occurrence and development in lung invasive adenocarcinoma. Combined detection of USP17 and MMP-9 have a certain significance in judging prognosis.