自拟过敏煎辅助治疗对小儿哮喘患者肺功能及预后影响的研究

Effect of Self-made Allergic Decoction on the Protection of Lung Function and Prognosis in Children with Asthma

目的观察自拟过敏煎辅助治疗对小儿哮喘患者肺功能保护以及预后的影响。方法选取哮喘患儿105例,随机分为对照组与治疗组。对照组给予孟鲁司特钠治疗,治疗组给予自拟过敏煎加孟鲁司特钠治疗。对比治疗后临床效果,记录患儿治疗前、治疗后核因子-κB(NF-κB)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)。第1秒用力呼气容积(FEV1)、第1秒最大呼气量/用力肺活量(FEV1/FVC)、用力呼气流量(PEF)变化。对比两组患儿咳嗽消失时间、气促消失时间、哮鸣音消失时间、不良反应发生率。对患儿进行6个月随访,比较两组患儿复发情况。结果治疗后,治疗组患儿总有效率94.55%明显高于对照组患儿总有效率82.00%(P <0.05);治疗后,两组患儿NF-κB、IL-6、IL-8表达水平均低于治疗前(P <0.05),且治疗组患儿治疗后指标明显低于对照组患儿(P <0.05);治疗后,两组患儿FEV1、FEV1/FVC、PEF等表达水平均高于治疗前(P <0.05);且治疗组患儿治疗后指标明显高于对照组患儿(P <0.05)。治疗后,治疗组患儿咳嗽消失时间、气促消失时间、哮鸣音消失时间均短于对照组患儿(P <0.05);治疗期间,两组患儿均有出现胃肠道反应、头晕、发热等不良反应,治疗组患儿发生率7.27%明显低于对照组患儿24.00%(P <0.05);对患儿进行6个月随访,结果表明治疗组患儿病情复发率为5.78%明显低于对照组患儿26.83%(P <0.05)。结论给予哮喘患儿自拟过敏煎辅助治疗,可缩短临床症状消失时间,改善患儿肺功能,降低炎症因子水平表达,降低不良反应发生率、复发率,提高临床治疗效果。

Objective: To investigate the effect of Self-made Allergic Decoction on the protection of lung function and prognosis in children with asthma. Methods: 105 asthmatic children were divided into treatment group(n = 55) and B group(n=50) according to different treatment methods. Control group was treated with montelukast sodium;treatment group was given Self-made Allergic Decoction and montelukast sodium. After treatment,the changes of NF-κB,IL-6,IL-8,FEV1,FEV1/FVC and PEF were recorded before and after treatment,and the cough in the two groups was compared. The time of disappearance of cough,breath and sound,and the incidence of adverse reactions were carried out for 6 months;the recurrence of the two groups was compared. Results: After treatment,the total effective rate of treatment group was 94.55%,significantly higher than that of control group(82.00%)(P < 0.05). The expression levels of NF-κB,IL-6 and IL-8 in two groups were lower than those before treatment(P < 0.05),and those in treatment group were significantly lower than those in control group(P < 0.05). The expression levels of FEV1,FEV1/FVC and PEF in two groups were higher than those before treatment(P < 0.05),and treatment group was significantly higher than control group(P < 0.05). After treatment,cough disappearance time,shortness of breath disappearance time and wheezing disappearance time in treatment group were shorter than those in control group(P < 0.05). During the treatment,gastrointestinal reactions,dizziness,fever and other adverse reactions occurred in both groups. The incidence of treatment group was 7.27%,significantly lower than that of control group(24.00%)(P < 0.05). During 6 months follow-up,the recurrence rate of treatment group was 5.78%,significantly lower than that of control group(26.83%)(P < 0.05). Conclusion: Self-made Allergic Decoction can shorten the time of disappearance of clinical symptoms,improve the pulmonary function of the children,reduce the expression of inflammatory factors,the incidence of adverse reactions and recurrence,and improve the effect of clinical treatment,worth popularizing in clinical practice.