凝血因子Ⅶ、CRP水平对老年人心肌梗死发生风险的影响研究

The Effect of Coagulation Factor Ⅶ and CRP Levels on the Risk of Myocardial Infarction in the Elderly

目的对凝血因子Ⅶ、C反应蛋白(C-reaction protein,CRP)水平对老年人心肌梗死发生风险的影响进行研究,以期为老年人心肌梗死患者的病情监测及个性化防治方案的制定提供参考依据。方法采用定群抽样的方法选取2015年3月至2017年8月某三甲医院心血管内科收治的老年(>60周岁)心肌梗死患者,同时选取等额数量基线资料具有可比性的非心肌梗死人群作为对照;采用ELISA法定量测定其凝血因子Ⅶ、CRP水平,于不同光波长下进行检测,用吸光度值(A)反映待测样品的浓度;并针对不同群体的资料进行统计分析。结果本研究共获得符合要求的观察对象125例,其中病例组60例,对照组65例;病例组和对照组受试者的凝血因子Ⅶ、CRP水平差异均有统计学意义,同时病例组中不同年龄组患者的凝血因子Ⅶ、CRP水平及其受体水平差异均有统计学意义(均有P <0.05);老年心肌梗死患者的凝血因子Ⅶ、CRP水平呈正相关(r=0.623,P<0.05)。结论高水平的凝血因子Ⅶ与CRP是老年心肌梗死发生的危险因素,年龄越大的心肌梗死患者凝血因子Ⅶ与CRP水平越高,同时凝血因子Ⅶ与CRP的水平具有正相关性。

Objective To study the effects of coagulation factor VII and CRP levels on the risk of myocardial infarction in the elderly,so to provide the reference for the monitoring of the condition of patients with myocardial infarction in the elderly and the development of personalized prevention and treatment programs.Methods A cluster sampling method was used to select elderly(>60 years old)patients with myocardial infarction admitted to the Department of Cardiology and Internal Medicine of a class A hospital from March 2015 to August 2017.At the same time,the equal amounts of baseline data were selected from the comparable non-myocardial infarction population as the control;the levels of coagulation factor VII and CRP were quantified by ELISA and the results were measured at different wavelengths of light.The absorbance(A)was used to reflect the concentration of the sample to be measured.The statistical analysis was performed on the data of different groups.Results A total of 125 patients who met the requirements were obtained in this study,including 60 in the case group and 65 in the control group.There were significant differences in the coagulation factor VII and CRP levels between the case group and the control group,and they were differences in the case group in coagulation factor VII and CRP levels and their receptor levels among different age sub-groups(all P<0.05);there was a positive correlation between coagulation factor VII and CRP levels in elderly patients with myocardial infarction(P=0.623,P<0.05).Conclusion High levels of coagulation factor VII and CRP are risk factors for the development of myocardial infarction in elderly patients.The older patients have the higher levels of coagulation factor VII and CRP,and there is a positive correlation between coagulation factor VII and CRP levels.