产后抑郁患者血清激素和NE、5-HT的相互关系及与防御机制成熟程度的关联研究

Association Study of Interrelated Postpartum Depression and Serum Hormone,NE,5-HT Levels and Maturity of the Defense Mechanism

目的分析产后抑郁患者防御方式与血清孕酮、NE以及5-HT水平之间的关联。方法研究选取本院分娩并随访确诊为产后抑郁症的患者98例纳入研究为实验组,随机选择同期参与评估的、SDS总分<41分的产妇32例作为对照组;实验组采用防御方式量表(DSQ)根据防御方式不同再次分为三组(不成熟防御机制组30例;成熟防御机制组35例;中间型防御机制组33例),检测产妇孕酮、NE以及5-HT水平,并进行比较,讨论与产后抑郁患者三种防御方式之间的关联。采用SPSS19.0统计软件分析处理数据。结果三组患者基本特征未见差别,充分可比,P>0.05。研究中三种防御机制的患者产前孕酮、NE以及5-HT水平在不同防御机制组中差别均未见统计学意义,P> 0.05;产后三个指标水平均低于产前水平,差别均有统计学意义,P<0.05;且产后的孕酮、NE以及5-HT水平在不成熟防御机制组患者中水平最低,差别有统计学意义,P<0.05;分析产后血清孕酮、NE以及5-HT水平与防御机制之间的相关性,可见产后孕酮水平、NE以及5-HT水平与防御机制的逐渐成熟之间成正相关,差异均有统计学意义,P<0.05。继续进一步分析三个指标之间的相互关联,可见分别均呈正相关,也均有统计学意义,P<0.05。结论产后抑郁的患者存在产后血清孕酮、NE以及5-HT水平的下降,且防御机制越不成熟,三个指标的水平相对越低。血清孕酮、NE以及5-HT水平与产后抑郁的发生存在潜在关联。

Objective To analyze the association between defensive mode and serum progesterone,NE,and 5-HT levels in postpartum depression patients.Methods 98 cases of postpartum depression diagnosed patients in our hospital were included in the study.According to different defense methods,they were divided into three groups:30 cases of immature defense mechanism group,35 cases of mature defense mechanism group,and 33 cases of intermediate defense mechanism group.These groups were examined with the levels of progesterone,NE,and 5-HT and compared to evaluate the relationship between defensive mode and the three types postpartum depression.SPSS19.0 statistical software package was used for the analysis and processing data.Results The three groups of patients were fully comparable with no difference in basic characteristics(P>0.05),which provided a good foundation for follow-up research.The differences in prenatal progesterone,NE,and 5-HT levels among the three defense mechanisms in the study were not significantly different(P>0.05);the levels of all three indicators for postpartum were lower than those of prenatal levels(P<0.05);and for postpartum levels of progesterone,NE,and 5-HT,all were found the lowest in patients with immature defense mechanisms(P<0.05).The correlation analysis showed that postpartum progesterone levels,NE,and 5-HT levels were positively correlated with the gradual maturation of defense mechanisms(P<0.05).Further analysis showed that there were positive correlations among three markers(P<0.05).Conclusion Postpartum depression patients have decreased postpartum serum progesterone,NE,and 5-HT levels,and the more immature defense mechanisms is,the lower the level of the three indicators are.The serum levels of progesterone,NE,and 5-HT are potentially associated with the occurrence of postpartum depression.