肥胖与结直肠癌的相关性研究

Study on the correlation between obesity and colorectal cancer

现今生活和饮食结构的改变,导致肥胖在正常人群中的患病比重不断增加,同时结直肠癌(colorectal cancer,CRC)在肥胖患者中又具有高发病率,虽然现已明确肥胖是结直肠癌发生的重要因素,但其具体的作用机制尚不明了。对于肥胖患者患结直肠癌的预后尚无定论,而肥胖悖论的提出引发了我们新的探索,对于患有结直肠癌的肥胖患者其中是否存在一定特异性相似以及其行新辅助治疗的必要性仍需要进一步研究。本文就肥胖与结直肠癌的临床关系以及一些特异性联系作一综述。

With the change of structure for life and diet,leading the prevalence of obese is increasing normal population,and colorectal cancer(CRC) has a high incidence in obese patients.Although it is clear that obesity is an important factor in CRC,but the definite mechanism is not clear.The prognosis for obese patients with colorectal cancer have been inconclusive,however,the appearance of obesity paradox causing us to have a new exploration.There is a need for further studies on whether there is a specific similarity between obese patients with colorectal cancer and the need for neoadjuvant therapy.The relationship between obesity and colorectal cancer is discussed in this paper and some specific connections are reviewed.