丙肝患者中HCV-RNA与ALT、AST、TBA、抗-HCV的相关性研究

Correlation between HCV-RNA and ALT, AST, TBA and Anti-HCV in Patients with Hepatitis C

目的研究丙肝患者HCV-RNA载量与ALT、AST、TBA、抗-HCV的相关性。方法方便选取于2014年7月—2017年7月该院收治的158例丙型肝炎患者,定量检测患者血清中HCV-RNA载量, ELISA法检测抗-HCV,同时联合检测血清中ALT、AST、TBA水平。结果 158例丙肝患者HCV-RNA载量与抗-HCV检测均为阳性的病例数为124例,占比为78.48%,HCV-RNA载量与抗-HCV无显著相关性(r=0.416,P>0.05);ALT、AST水平及异常率与HCV-RNA载量呈正相关(P<0.05); TBA水平及异常率与HCV-RNA载量呈正相关(r=0.712,P<0.05)。结论 HCV-RNA载量与ALT、AST、TBA水平存在相关性,联合检测HCV-RNA载量、抗-HCV及ALT、AST、TBA可一定程度反映肝脏受损状况,提高丙型肝炎的检出率,为丙型肝炎的诊断治疗提供可靠的临床依据。

Objective To study the correlation between HCV-RNA load and ALT,AST,TBA and anti-HCV in patients with hepatitis C.Methods A total of 158 patients with hepatitis C admitted to our hospital from July 2014 to July 2017 were convenient enrolled.Quantitative detection of HCV-RNA load in patients'serum,detection of anti-HCV by ELISA,and simultaneous detection of ALT and AST,TBA level in serum.Results The number of HCV-RNA carriers and anti-HCV tests in 158 patients with hepatitis C was 124 case,accounting for 78.48%.There was no significant correlation between HCV-RNA load and anti-HCV(r=0.416,P>0.05);ALT,AST level and abnormal rate were positively correlated with HCV-RNA load(P<0.05);TBA level and abnormal rate were positively correlated with HCV-RNA load(r=0.712,P<0.05).Conclusion There is a correlation between HCV-RNA load and ALT,AST and TBA levels.Combined detection of HCV-RNA load,anti-HCV and ALT,AST and TBA can reflect the liver damage and improve the detection rate of hepatitis C of outflow provides a reliable clinical basis for the diagnosis and treatment of hepatitis C.