自噬与凋亡在骨肉瘤中的作用

Role of Autophagy and Apoptosis in Osteosarcoma

骨肉瘤是儿童和青少年中最常见的原发性骨肿瘤,其恶性程度高,严重影响患者的生存。虽然手术和多靶点化疗的联合治疗使得患者整体的生存率有了大幅度的提高,但化疗耐药仍然是骨肉瘤治疗的阻碍。骨肉瘤化疗耐药与其在发生发展过程中的凋亡和自噬等有一定关系。现在骨肉瘤中细胞凋亡、自噬的机制以及相互作用已经被初步探索,参与细胞凋亡、自噬的分子靶点、介质及相关机制已经开始研究,这对缓解骨肉瘤治疗过程中的化学耐药指导引领新的方向。

Osteosarcoma is the most common primary bone tumor in children and adolescents with high malignancy, seriously affecting the survival of the patients.Although the combination of surgery and multi-target chemotherapy has greatly improved the overall survival rate,chemotherapy resistance is still an obstacle to the treatment.Chemotherapy resistance of osteosarcoma is related to apoptosis and autophagy during its development.The mechanism of apoptosis and autophagy and the relationship between them have been preliminarily explored in osteosarcoma,and the molecular targets,medium and relevant mechanisms of apoptosis, autophagy have begun to be studied,which provides a new direction for relieving the chemical resistance during osteosarcoma treatment.