外周血红细胞分布宽度、嗜酸性粒细胞计数及血清总IgE与儿童哮喘的关系

Relationship between peripheral red blood cell distribution width,eosinophil count,serum total IgE and asthma in children

目的探讨外周血红细胞分布宽度(red blood cell distribution width,RDW)、嗜酸性粒细胞(eosinophil,EOS)计数及血清总Ig E(immunoglobulin E)与儿童哮喘(childhood asthma)的关系。方法收集2017-05～2018-05收治的支气管哮喘患儿60例,并根据病情严重程度将其分为轻度组和中重度组,设立同期健康体检儿童35例为对照组,测定各组RDW、EOS及Ig E水平。结果与对照组相比,哮喘组RDW、EOS及Ig E水平均明显升高,差异均有统计学意义(P<0.001);中重度组RDW、Ig E水平明显高于轻度组,差异有统计学意义(P<0.001),而EOS在两组之间的差异无统计学意义(P> 0.05)。ROC曲线分析结果显示,RDW、EOS及Ig E诊断儿童哮喘的曲线下面积分别为0. 736,0. 757,0. 783。相关性分析结果显示,哮喘组RDW与Ig E之间呈正相关性(r=0. 272,P<0.05),而RDW与EOS(r=-0. 032,P>0.05)、EOS与Ig E(r=-0.017,P>0.05)之间均无相关性。结论哮喘患儿RDW、EOS及Ig E水平均升高,且RDW、Ig E水平与患儿病情严重程度呈正相关性,监测RDW、EOS及Ig E水平对于儿童哮喘的诊断具有重要的临床意义,且RDW、Ig E可用于评估患儿的病情。

Objective To explore the relationship between peripheral red blood cell distribution width(RDW),eosinophil(EOS) count,serum total immunoglobulin E(IgE) and asthma in children. Methods Sixty children with bronchial asthma from May 2017 to May 2018 were chosen and divided into mild group and moderate-severe group based on the severity of the disease.And thirty-five healthy children at the same period were taken as control group.RDW,EOS and IgE were measured in all groups. Results Compared with control group,the levels of RDW,EOS and IgE in asthma group were significantly increased( P<0.001).The levels of RDW and IgE in moderate-severe group were significantly higher than those in mild group( P<0.001),but there was no significant difference in the level of EOS between these two groups( P>0.05).ROC curve analysis showed that the ROC area under the curve of RDW,EOS and IgE in diagnosis of asthma in children was 0.736,0.757,0.783,respectively.Correlation analysis showed that RDW was positively correlated with IgE( r =0.272, P<0.05),but there was no correlation between RDW and EOS( r =-0.032, P>0.05),EOS and IgE( r =-0.017, P>0.05) in children with asthma. Conclusion The levels of RDW,EOS and IgE in children with asthma are elevated,and the levels of RDW,IgE are positively correlated with the severity of asthma. Monitoring the levels of RDW,EOS and IgE has a clinical significance for the diagnosis of asthma in children,and RDW,IgE can be used to assess the severity.