美托洛尔联合用药治疗慢性心力衰竭的效果研究

Study on the effect of Metoprolol combined with drugs in the treatment of chronic heart failure

目的探讨美托洛尔联合用药治疗慢性心力衰竭的效果及对患者心功能的影响。方法选取慢性心力衰竭患者100例,随机分为2组各50例。对照组口服美托洛尔,研究组在美托洛尔的基础上联合复方强心汤进行治疗,对比2组心功能、临床疗效以及不良反应发生情况。结果研究组临床疗效和总有效率优于或高于对照组,差异均有统计学意义(P<0.05)。治疗后研究组左心室舒张末期内径(left ventricular end-diastolic dimension,LVEDD)和左心室收缩末期内径(left ventricular end-systolic dimension,LVESD)水平明显低于治疗前和对照组,差异均有统计学意义(P<0.05)。治疗后研究组左心室射血分数(left ventricular ejection fraction,LVEF)、左心室舒张早期充盈峰E峰/舒张晚期充盈的充盈峰A峰(E/A)和6分钟步行试验(6-minute walking test,6-MWT)水平明显高于治疗前和对照组,差异均有统计学意义(P<0.05)。治疗后2组心型脂肪酸结合蛋白(heart fatty acid binding protein,H-FABP)、正五聚蛋白3(pentraxin-3,PTX-3)、N-末端脑钠肽前体(nervous terminal pro-brain natriuretic peptide,NT-Pro-BNP)明显低于治疗前和对照组,差异均有统计学意义(P<0.05)。2组不良反应发生率差异无统计学意义(P>0.05)。结论美托洛尔联合复方强心汤能有效改善患者心功能,且不良反应发生率低,值得进一步推广应用。

Objective To explore the effect of metoprolol combined with drugs on chronic heart failure and cardiac function of patients.Methods One hundred patients with chronic heart failure were randomly divided into two groups,50 in each group.The control group was given metoprolol orally,while the study group was treated with compound Qiangxin Decoction on the basis of metoprolol.The cardiac function,clinical efficacy and adverse reactions of the two groups were compared.Results The clinical efficacy and total effective rate of the study group were higher than those of the control group,and the differences were statistically significant(P<0.05).Left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic dimension(LVESD)level after treatment in two groups were significantly lower than before treatment,the differences were statistically significant(P<0.05).LVEDD and LVESD levels after treatment study group were significantly lower than the control group,the difference was statistically significant(P<0.05).Left ventricular ejection fraction(LVEF),left ventricular diastolic filling peak E peak early/late diastolic filling of the filling A peak peak(E/A)and 6-minute walking test(6-MWT)after treatment study group were significantly higher than those before treatment and the control group,with statistically significant differences(P<0.05).Heart fatty acid binding protein(H-FABP),pentraxin-3(PTX-3),and nervous terminal pro-brain natriuretic peptide(NT-Pro-BNP)after treatment study group were significantly lower than before treatment and the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P > 0.05).Conclusion Metoprolol combined with compound Qiangxin Decoction can effectively improve the cardiac function of patients,and the incidence of adverse reactions is low,which should be further promoted and applied.