DC-CIK细胞免疫疗法在肝细胞癌治疗中的应用进展

Application of DC-CIK cellular immunotherapy in hepatocellular carcinoma: a review

肝癌是临床上常见的恶性肿瘤,病死率高,大部分患者患病时已失去最佳手术治疗时机。目前主要的保守治疗方法有超声引导下肿瘤射频消融、肝动脉栓塞疗法、生物免疫治疗以及分子靶向治疗等。因肝癌是一种免疫相关疾病,为探索有效的细胞免疫治疗方案,提高患者生存率及生活质量,该文就树突状细胞-细胞因子诱导的杀伤细胞(DC-CIK)免疫疗法在肝癌治疗中的应用进行了综述。

Hepatocellular carcinoma (HCC) is a common malignant tumor with high mortality. Most patients lose the best opportunity for surgical treatment when diagnosed. The main conservative therapies are ultrasound-guided radiofrequency ablation, hepatic artery embolization therapy, bio-immunotherapy and molecular targeted therapy. Because hepatocellular carcinoma is an immune-related disease, in order to explore effective cellular immunotherapy regimen and improve the survival rate and quality of life of patients, this article reviews the application of dendritic cells and cytokine-induced killer (DC-CIK) immunotherapy in hepatocellular carcinoma.