人参五味消毒饮灌肠对烧伤脓毒血症患者血清炎性因子的影响

Effect of drug enema with Ginseng Wuwei Xiaodu drink on serum inflammatory factors in patients with burn sepsis

目的观察人参五味消毒饮灌肠对烧伤脓毒血症患者临床疗效及血清炎性因子肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)以及白介素-6(IL-6)的影响。方法 68例烧伤脓毒血症患者随机分为观察组、对照组,两组均给予常规西医治疗,但观察组增加人参五味消毒饮灌肠。比较两组临床疗效、炎性因子(TNF-α、CRP、IL-6)水平、Mashall评分、急性生理与慢性健康(APACHEⅡ)评分变化。结果观察组疗效明显优于对照组(88.2%vs 55.9%,P<0.01),而血清TNF-α、CRP、IL-6水平及Mashall、APACHEⅡ评分明显低于对照组(P<0.01或0.05)。结论人参五味消毒饮灌肠可提高烧伤脓毒血症疗效,降低血清炎性因子水平。

Objective To observe the clinical efficacy of drug enema with Ginseng Wuwei Xiaodu drink(GWXD) and its impact on serum inflammatory factors [ tumor necrosis factor-α(TNF-α), C-reactive protein(CRP) and interleukin-6(IL-6)]in burn sepsis. Methods Sixty-eight patients with burn sepsis were treated with routine Western medicine(control group) and additional GWXD enema(observation group). Clinical efficacy, serum levels of inflammatory factors(TNF-α, CRP and IL-6),and Mashall and acute physiology and chronic health(APACHE II) scores were compared between both groups. Results Compared with control group, clinical efficacy was increased(88.2% vs 55.9%, P<0.01), but serum TNF-α, CRP and IL-6 levels and Mashall and APACHE II scores were decreased(P<0.01 or 0.05) in observation group. Conclusion GWXD enema can improve the curative effect and reduce the serum levels of inflammatory factors in patients with burn sepsis.