慢性髓细胞白血病不同临床缓解状态下的T细胞亚群特点研究

The characterization of T cell subtypes under different clinical remissions of chronic myeloid leukemia

目的探讨不同临床缓解状态下慢性髓细胞白血病(CML)患者T细胞亚群特点。方法 104例CML患者分为未缓解组(n=24),细胞遗传学缓解(CCyR)组(n=13),主要分子生物学缓解4. 5(MR4. 5)组(n=67),流式检测外周血CD8+T及CD4+T亚群Th1、Th2、Treg。结果未缓解组、CCyR组、MR4. 5组分别有62. 50%、15. 38%及15. 15%的患者Th1低于正常下限。未缓解组Th1降低率高于CCyR组及MR4. 5组,Th1平均值低于CCyR组及MR4. 5组(P <0. 05)。Treg、Th2及CD8+T三组间差异无统计学意义(P> 0. 05)。结论 CML患者良好的临床缓解状态表现出较高的Th1水平。

Objective To investigates the T cell subtypes of patients with chronic myeloid leukemia(CML)in different clinical remission situations.Methods One hundred and four CML patients at chronic-phase were divided into unremission group(n=24),complete cytogenetic response(CCyR)group(n=13),and molecular response4.5(MR 4.5)group(n=6 7).The peripheral blood of the patients was collected and analyzed by flow-cytometry for levels of CD8^+T and CD4^+T cell subtypes as well as Th1,Th2 and Treg.Results Th1 level below the low limit of normal was found in 62.50%of the patients in the unremission group,15.38%in the CCyR group and 15.15%in the MR4.5 group,respectively.The percentage of low-Th1 patients in the unremission group was significantly higher than that in the CCyR group and the MR4.5 group(P<0.05).For the comparison of Treg,there was no statistically significant difference in Th2 and CD8^+T proportions among the three groups(P>0.05).Conclusion The better clinical remission situations of CML patients show a higher Th1 level.