益气养阴活血汤配合普罗帕酮治疗心律失常的疗效及对血清hs-CRP的影响

Effect of Yiqi Yangyin Huoxue Decoction and Propafenone on Arrhythmia and its Effect on Serum hs-CRP

目的观察益气养阴活血汤联合普罗帕酮应治疗心律失常患者的临床疗效及对血清超敏C-反应蛋白(hs-CRP)的影响。方法选取92例心律失常患者为研究对象,随机分为研究组与对照组,各46例。对照组患者给予普罗帕酮治疗,研究组在此基础上给予益气养阴活血汤治疗,评价2组临床疗效,对比治疗前后2组心功能指标、血清hs-CRP水平变化,观察2组不良反应发生情况。结果研究组与对照组患者的总有效率分别为93.48%、71.74%,2组对比差异有统计学意义(P<0.05);治疗后,研究组与对照组患者的LVESD、LVEDD均较治疗前降低,LVEF较治疗前升高(P<0.05),且研究组的LVESD、LVEDD低于对照组,LVEF高于对照组(P<0.05);研究组与对照组的hs-CRP水平均较治疗前降低,研究组的hs-CRP水平低于对照组(P<0.05);研究组不良反应发生率明显低于对照组(P<0.05)。结论益气养阴活血汤联合普罗帕酮治疗心律失常临床疗效明显,可下调hs-CRP水平,改善患者心功能,安全性良好。

Objective To explore the clinical efficacy of Yiqi Yangyin Huoxue Decoction combined with propafenone in the treatment of arrhythmia, and to analyze the effect of it on serum hypersensitivity C- reactive protein(hs-CRP). Methods 92 cases of arrhythmia in our hospital from June 2015 to December -2017 were selected and randomly divided into the study group and the control group, 46 cases in each group. The patients in the control group were treated with propafenone. On this basis, the patients in the study group were treated with Yiqi Yangyin Huoxue Decoction. After the treatment, the clinical efficacy of two groups of patients was evaluated. The changes of cardiac function index and serum hs-CRP level in the two groups before and after treatment were compared, and the incidence of adverse reactions in the two groups was observed. Results The total effective rate of the study group and the control group was 93.48% and 71.74% respectively, and the difference of the two groups was statistically significant(P<0.05). After the treatment, the LVESD and LVEDD of the study group and the control group were lower than those before the treatment, and the LVEF was higher than that before the treatment(P<0.05), and the LVESD and LVEDD in the study group were lower than those in the control group, LVEF was higher than that of the control group. In the control group(P<0.05), the level of hs-CRP in the study group and the control group was lower than that before the treatment, and the level of hs-CRP in the study group was lower than that of the control group(P<0.05), and the incidence of adverse reactions in the study group was significantly lower than that of the control group(P<0.05). Conclusion Yiqi Yangyin Huoxue Decoction combined propafenone in the treatment of arrhythmia clinical effect is significant, can reduce the level of hs-CRP, improve the patient's heart function, and high safety, worthy of clinical promotion.