无症状高血尿酸血症与原发性高血压关系的临床研究

Relationship between Asymptomatic Hyperuricemia and Essential Hypertension: a Clinical Study

目的探讨无症状高血尿酸血症与原发性高血压的关系。方法选择2017年6月—2018年7月间连州市人民医院内科收治的200例住院高血压患者,纳入研究组,所有患者入院后,嘱咐其空腹> 8 h,于次日晨测定血尿酸水平,同时监测血压。再将研究组200例患者按照血压水平划分为3个亚组,包括轻度亚组、中度亚组、重度亚组;全部进行治疗,2周后再次测量血压水平,评估疗效。选择同期内科住院患者或门诊健康体检者200例,纳入对照组,测量血尿酸水平步骤同研究组,评估2组患者无症状高血尿酸例数,判断高血压病发病率与无症状高血尿酸血症的关系。结果研究组中,无症状高血尿酸血症患者共101例(50. 50%),高于对照组44例(22. 00%),P <0. 05;研究组中,轻度高血压亚组40例(20. 00%)、中度亚组67例(33. 50%)、重度亚组93例(46. 50%)。随着血压水平的升高血尿酸水平也处于增高趋势,轻度、中度、重度高血压亚组血尿酸水平比较均有统计学意义,P <0. 05。40例轻度高血压亚组患者基本治愈28例(70. 00%),67例中度高血压亚组患者基本治愈17例(25. 37%),93例重度高血压亚组患者基本治愈31例(33. 33%)(F=22. 779,P <0. 05)。研究组患者经治疗后血压得到控制,血尿酸水平明显下降。结论血尿酸升高是引发高血压的独立危险因素。

Ojbective To explore the relationship between asymptomatic hyperuricemia and essential hypertension.Methods 200 patients with hypertension admitted by the Department of Internal Medicine of Lianzhou People′s Hospital from June 2017 to July 2018 were enrolled in the study.All patients were instructed to keep fasting for more than 8 hours after admission.The level of serum uric acid was measured in the next morning and blood pressure was monitored at the same time.Then all patients were divided into three groups according to blood pressure level:mild,moderate and severe group.All patients were treated,and blood pressure level was measured again after 2 weeks to evaluate the curative effect.200 healthy inpatients or outpatients in the same period were enrolled in the control group.The blood uric acid level was measured and compared with the study group.The number of asymptomatic hyperuricemia cases in the two groups was evaluated to investigate the relationship between the incidence of hypertension and asymptomatic hyperuricemia.Results In the study group,101 cases(50.50%)were asymptomatic hyperuricemia,which was 44 cases(22.00%)higher than that in the control group(P<0.05).In the study group,40 cases(20.00%)were in mild hypertension group,67(33.50%)in moderate hypertension group and 93 cases(46.50%)in severe hypertension group.With the increase of blood pressure,the level of serum uric acid was also on the rise.The comparison results of serum uric acid levels in the three groups were statistically significant(P<0.05).The basic cure rate was 28 cases(70.00%)in 40 patients with mild hypertension,17 cases(25.37%)in 67 patients with moderate hypertension and 31 cases(33.33%)in 93 patients with severe hypertension(F=22.779,P<0.05).The blood pressure of the experimental group was controlled after treatment,and the level of serum uric acid decreased significantly.Conclusion Elevated serum uric acid is an independent risk factor for hypertension.