过敏原阻隔剂对鼻喷激素联合鼻腔冲洗治疗变应性鼻炎的疗效影响

Influence of allergen blocker on efficacy of nasal spray hormone combined with nasal irrigation in treatment of allergic rhinitis

目的观察过敏原阻隔剂对糠酸莫米松鼻喷雾剂联合鼻腔冲洗治疗变应性鼻炎的疗效影响及安全性。方法选取2016年9月至2017年5月在本院耳鼻喉科门诊诊治的变应性鼻炎患者110例,随机列表法分为对照组和观察组,每组各55例。两组均进行鼻腔冲洗,冲洗后对照组给予糠酸莫米松鼻喷雾剂治疗,观察组在对照组基础上加用过敏原阻隔剂治疗,比较两组治疗前后的临床疗效及用药期间不良反应情况。结果治疗后观察组的鼻痒、鼻塞、喷嚏、清水样涕症状及生活质量评分均明显低于对照组(P<0.05);观察组治疗效果的总有效率为89.1%,优于对照组的72.7%,差异有统计学意义(P<0.05);鼻内镜下两组患者鼻部综合体征评分比较差异有统计学意义(P<0.01)。结论过敏原阻隔剂联合糠酸莫米松鼻喷雾剂及鼻腔冲洗治疗变应性鼻炎临床疗效明显,安全性好,值得临床推广应用。

Objective To observe the effect and safety of allergen blocker on the treatment effect of mometasone furoate nasal spray combined with nasal irrigation for treating allergic rhinitis.Methods A total of 110 patients with allergic rhinitis diagnosed and treated in the otolaryngology department of this hospital from September 2016 to May 2017 were selected and divided into the control group and the observation group by adopting the random tabulation method,55 cases in each group.Nasal lavage was performed in both groups.After washing,the control group was treated with mometasone furoate nasal spray.The observation group was added with allergen blocker on the basis of the control group.The clinical efficacy and adverse reactions during the medication before and after treatment were compared between the two groups.Results The symptoms of nasal itching,nasal congestion,sneezing,watery sputum and life quality score after treatment in the observation group were significantly lower than those in the control group(P<0.05).The total effective rate of the treatment in the observation group was 89.1%,which was superior to 72.7%in the control group,and the difference was statistically significant(P<0.05).The nasal comprehensive physical sign scores under nasal endoscopy had statistical difference between the two groups(P<0.01).Conclusion The allergen blocker combined with mometasone furoate nasal spray and nasal irrigation for the treatment of allergic rhinitis has obvious clinical efficacy and good safety,and is worthy of clinical promotion and application.