糖尿病合并急性冠状动脉综合征与血浆网膜素水平的关系研究

Study on relationship between diabetes complicating acute coronary syndrome with plasma omentin level

目的评价糖尿病合并急性冠状动脉综合征与血浆网膜素水平的关系。方法选择该院心内科及内分泌科糖尿病合并冠心病患者45例,均经冠状动脉造影确定至少一支冠状动脉直径狭窄程度大于或等于50%者为试验组,其后再根据患者的具体临床症状分出不稳定型心绞痛(UAP)和急性心肌梗死(AMI)两亚组。对照组选择同期于该院就诊,经冠状动脉造影确定冠状动脉直径狭窄程度小于50%的糖尿病患者40例,其后也根据患者的具体临床症状分出UAP和AMI两亚组。采用酶联免疫吸附试验(ELISA)检测患者网膜素水平。结果冠状动脉狭窄程度大于或等于50%的糖尿病患者男性比例、AMI例数均高于对照组(P<0.01),网膜素水平低于对照组(P<0.01)。而年龄、UAP例数差异均无统计学意义(P>0.05)。结论血浆网膜素水平与糖尿病患者冠状动脉病变严重程度密切相关,而冠状动脉病变严重程度与急性冠状动脉综合征显著相关。

Objective To evaluate the relationship between diabetes complicating acute coronary syndrome with plasma omentin levels.Methods Forty-five patients with diabetes complicating coronary heart disease in the cardiology and endocrinology department of this hospital were selected,and those confirmed as at least one coronary artery diameter stenosis degree≥50%by coronary angiography served as the experimental group.Then they were divided into the unstable angina subgroup(UAP)and acute myocardial infarction(AMI)subgroup according to the specific clinical symptoms.At the same time 40 diabetic patients with coronary artery diameter stenosis degree<50%confirmed by coronary angiography were selected as the control group,and then they were divided into the UAP subgroup and AMI subgroup.The omentin level was measured by adopting the enzyme-linked immunosorbent assay(ELISA).Results The male proportion and AMI cases in diabetic patients with coronary artery stenosis degree≥50%were higher than those in the control group(P<0.01),while the omentin level was significantly lower than that in the control group(P<0.01).The age and UAP cases had no statistically significant difference between the experimental group and the control group(P>0.05).Conclusion The plasma omentin level is closely correlated to the severity of coronary artery lesion in diabetic patients,while the severity of coronary arterial lesion is significantly correlated with acute coronary syndrome.