2型糖尿病伴OSAHS患者血清HCY、SAA水平与认知功能的关系研究

Research on relationship between level of HCY and SAA with cognitive function in patients with type 2 diabetes mellitus complicating OSAHS

目的探讨2型糖尿病伴阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清同型半胱氨酸(HCY)、淀粉样蛋白A(SAA)水平与认知功能的关系。方法分别测定62例2型糖尿病伴OSAHS患者、35例单纯2型糖尿病患者,以及同期37例健康体检者(对照组)的血清HCY、SAA水平,测定蒙特利尔认知评估量表(MoCA)得分,分析3组人群血清HCY、SAA水平与认知功能的关系。结果 (1)2型糖尿病伴OSAHS组、2型糖尿病组MoCA总分及视空间、命名、注意力、语言、抽象、记忆、定向评分低于对照组,其中以2型糖尿病伴OSAHS组更为显著,差异有统计学意义(P<0.05);(2)与对照组相比,2型糖尿病伴OSAHS组、单纯2型糖尿病组患者血清HCY、SAA水平均有增高,其中以2型糖尿病伴OSAHS组增高更为显著,差异有统计学意义(P<0.05);(3)与单纯2型糖尿病组相比,2型糖尿病伴OSAHS组合并认知障碍患者,血清HCY、SAA水平升高,差异有统计学意义(P<0.05)。结论 2型糖尿病伴OSAHS患者存在较高的认知功能障碍发生率,血清HCY、SAA水平对于认知障碍发生就有一定的提示作用。

Objective To investigate the relationship between the levels of serum homocysteine(HCY)and serum amyloid A(SAA)with the cognitive function in the patients with type 2 diabetes mellitus(T2DM)complicating obstructive sleep apnea hypopnea syndrome(OSAHS).Methods The serum HCY and SAA levels in 62 patients with T2DM complicating OSAHS,35 patients with simple T2DM and contemporaneous 37 healthy persons undergoing physical examination(control group)were measured respectively.The score of Montreal cognitive assessment scale(MoCA)was detected.Then the relationship between serum HCY and SAA levels with the cognitive function was analyzed.Results(1)The MoCA total score,scores of visual space,naming,attention,language,abstraction,memory,and orientation in the T2DM complicating OSAHS group and simple T2DM were lower than those in the control group,moreover which in the T2DM complicating OSAHS was more significant,and the difference was statistically significant(P<0.05);(2)Compared with the control group,the serum HCY and SAA levels in the T2DM complicating OSAHS group and simple T2DM group were increased,moreover the increase in the T2DM complicating OSAHS was more significant,and the difference was statistically significant(P<0.05);(3)compared with the simple T2DM group,the serum HCY and SAA levels in the T2DM complicating OSAHS group were increased,and the difference was statistically significant(P<0.05).Conclusion The patients with T2DM complicating OSAHS have higher inci-dence rate of cognitive dysfunction.So the serum HCY and SAA levels have a prompting effect for the occurrence of cognitive impairment.