帕金森患者非运动症状与认知功能关系的研究

The Relationship between Non-Motor Symptoms and Cognitive Function in Parkinson's Patients

目的研究帕金森(PD)患者非运动症状对远期认知功能的影响。方法纳入符合标准的PD患者64例,其中男性37例,采用帕金森病综合评量表的第一部分评估患者的非运动症状(NMS),MMSE评估患者的总体认知功能,对基线的非运动症状与2年后的MMSE总分行多因素回归分析。结果调整性别、年龄、教育水平、高血压病史、糖尿病病史、H-Y分级和PD病程后,基线NMS对总体认知功能的回归分析β=-1. 1; 95%CI=(-1. 8,-0. 4); P=0. 005。结论非运动症状增加2年后总体认知功能受损的风险。

Objective To study the effect of non-motor symptoms(NMS)on 2-years cognitive function in Parkinson's patients(PD).Methods In the study,64 PD patients were enrolled.The NMS were assessed by the first part of the Parkinson's Disease Comprehensive Rating Scale(UPDRS-I).The global cognitive function was assessed by MMSE.Statistical analysis used multivariate regression analysis.Results After adjusted for gender,age,education,hypertension history,diabetes history,H-Y classification and PD course,the regression analysisβ(95%CI)P of baseline NMS for global cognitive function was-1.1(-1.8,-0.4)0.005.Conclusion For PD patients,the motor symptoms increase the risk of 2-years global cognitive impairment.