双歧杆菌三联活菌胶囊联合奥沙利铂对结直肠癌术后的疗效及对肠道菌群与免疫功能的影响

Curative efficacy of bifidobacterium triple viable capsule combined with oxaliplatin in treatment of postoperative colorectal cancer and its effects on intestinal flora and immune function

目的探讨双歧杆菌三联活菌胶囊联合奥沙利铂对结直肠癌术后的疗效及对肠道菌群、免疫功能的影响。方法选择2016年1月～2016年12月于我院行结直肠癌术的患者86例作为研究对象,随机将所有患者分为观察组和对照组,各43例。所有患者均顺利完成结直肠癌术,术后给予常规化疗方案,对照组在此基础上加用奥沙利铂辅助治疗,观察组患者在对照组基础上联合双歧杆菌三联活菌胶囊进行治疗。比较两组肠道菌群水平、白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、免疫球蛋白水平、血浆D-乳酸、粪便S-lgA水平及不良反应。结果治疗后,观察组双歧杆菌、乳酸杆菌、及粪肠球菌水平均高于对照组,大肠杆菌水平低于对照组(P<0.05);观察组IL-6、CRP及TNF-α水平均低于对照组(P<0.05);观察组CD4^+及CD4^+/CD8^+均高于对照组,CD8^+低于对照组(P<0.05);观察组血浆D-乳酸低于对照组,粪便S-lgA水平高于对照组(P<0.05);观察组不良反应发生率低于对照组(P<0.05)。结论结直肠癌术后采用双歧杆菌三联活菌胶囊联合奥沙利铂辅助化疗可有效调节机体肠道菌群,重建肠道微生态平衡,同时促进肠黏膜屏障功能恢复,提高机体免疫功能,且安全性好,可在临床推广应用。

Objective To explore curative efficacy of bifidobacterium triple viable capsule combined with oxaliplatin in treatment of postoperative colorectal cancer and its effects on intestinal flora and immune function.Methods 86 patients underwent colorectal cancer surgery in our hospital from January 2016 to December 2016 were selected as the study subjects.All patients were randomly divided into observation group and control group,43 cases in each.All patients were successfully completed colorectal cancer surgery,postoperative conventional chemotherapy.The control group was treated with adjuvant oxaliplatin.The observation group was treated with triple viable capsule.The levels of intestinal flora,interleukin-6 (IL-6),C-reactive protein (CRP),tumor necrosis factor-α(TNF-α),immunoglobulin,plasma D-lactate,-lgA levels and adverse reactions were observed.Results After treatment,Bifidobacterium,Lactobacillus,and Enterococcus faecalis levels of the observation group were higher than that of the control group.Escherichia coli levels the observation group were lower than that of the control group(P<0.05).The levels of IL-6,CRP and TNF-α in the observation group were lower than those in the control group(P<0.05).The levels of CD4^+ and CD4^+/ CD8^+ in the observation group were significantly higher than those in the control group (P<0.05).The level of CD8^+ in the observation group was lower than that in the control group (P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Colorectal cancer after surgery with bifidobacterium triple viable capsules plus oxaliplatin adjuvant chemotherapy can effectively regulate the body's intestinal flora,rebuild the intestinal microflora balance,while promoting intestinal mucosal barrier function recovery,and improve immune function,and have Good safety.