经直肠前列腺超声造影联合血清PSA诊断前列腺癌的价值研究

The value of transrectal ultrasonography combined with serum PSA in the diagnosis of prostate cancer

目的研究经直肠前列腺超声造影联合血清前列腺特异性抗原(PSA)诊断前列腺癌的价值,为临床诊治提供参考。方法回顾性分析大连大学附属中山医院2016年1月至2018年1月诊治的126例前列腺疾病患者的临床资料,所有患者治疗前均行直肠前列腺超声造影、血清PSA检查。将术后病理结果作为金标准,对比经直肠前列腺超声造影、PSA、超声联合PSA诊断的特异性、敏感性和准确性,经直肠前列腺超声造影、PSA、超声联合PSA病理诊断结果的Kappa一致性系数。结果经直肠前列腺超声造影、PSA、超声联合PSA与手术病理诊断的Kappa一致性系数分别为0.73、0.71和0.87,超声联合PSA诊断前列腺癌一致性最高。超声联合PSA诊断前列腺癌的特异度为88.2,准确度为84.9,灵敏度为78.1,均高于单独的经直肠前列腺超声造影和PSA。结论经直肠前列腺超声造影联合血清PSA诊断前列腺癌,其特异性、灵敏度和准确性均较高,且与病理学诊断一致性最好,值得临床借鉴。

Objective To evaluate the diagnostic value of transrectal ultrasound combined with serum pros-tate specific antigen (PSA) in prostate cancer, so as to provide references for clinical diagnosis and treatment. Methods The clinical data of 126 patients with prostate disease admitted in Zhongshan Hospital Affiliated to Dalian University from January 2016 to January ~2018 were retrospectively analyzed. All patients underwent rectal ultrasound and PSA examination before treatment. The postoperative pathological results were taken as the gold standard. The specificity, sensitivity and accuracy of contrast-enhanced ultrasound, PSA and ultrasound combined with PSA were compared. The Kappa coherence coefficient of transrectal ultrasound, PSA and ultrasound combined with PSA pathology diagnosis were compared. Results The specificity and specificity of ultrasound combined with PSA in diagnosing prostate cancer were 88.2, 84.9 and 78.1, respectively, which were higher than those of single tran-srectal ultrasound and PSA. The Kappa conformance coefficient of transrectal ultrasound, PSA and ultrasound combined with PSA is 0.73, 0.71 and 0.87, respectively. Ultrasound combined with PSA is the most consistent diagnostic method for prostate cancer. Conclusions Transrectal ultrasound combined with serum PSA in diagnosis of prostate cancer has high specificity, sensitivity and accuracy, and is consistent with pathological diagnosis. It is worthy of clinical reference.