腹腔镜手术治疗早期子宫颈癌的近期疗效与应用价值

Short-term efficacy and clinical value of laparoscopic surgery for early cervical cancer

目的分析探讨腹腔镜手术治疗早期子宫颈癌的近期疗效与应用价值。方法根据研究相关标准,选择需要进行手术治疗的240例早期宫颈癌患者为研究对象,按照随机数字表法将其分为观察组(腹腔镜手术)和对照组(开腹术);比较两组患者手术指标、恢复情况和并发症发生情况;比较两组患者切缘阳性率、术前和术后3个月血清雌二醇(E2)和25-羟基维生素D[25(HO)D]水平,统计治疗总有效率。结果与对照组患者相比,观察组患者出血量更少,排气时间、下床活动时间、住院时间更短;观察组患者盆腔感染、尿潴留、肠梗阻、切口感染发生率均低于对照组患者;观察组患者术后3个月E2低于对照组患者,25(OH)D水平高于对照组患者;观察组患者治疗总有效率(87.5%)高于对照组患者(70.0%):其差异均具有统计学意义(均P<0.05)。两组患者切缘阳性率比较,其差异无统计学意义(P>0.05)。结论腹腔镜手术治疗早期宫颈癌能够促进患者下床活动和出院,降低并发症发生率,近期效果好于开腹术,且安全性高,具有重要推广价值。

Objective To explore the short-term efficacy and clinical value of laparoscopic surgery in the treatment of early cervical cancer. Methods According to the relevant criteria, 240 patients with early cervical cancer who underwent surgical treatment were randomly divided into observation group (laparoscopic surgery) and control group (laparotomy). The operation indicators, recovery and incidence of complications were compared between the two groups. The positive rate of incision edge was compared and the serum estradiol ( E2 ) and 25- hydroxy vitamin D [25 (HO) D] levels were compared between before and 3 months after operation, and the total effective rate was statistically analyzed. Results The incidences of pelvic infection, urinary retention, intestinal obstruction and incision infection in the observation group were lower than those in the control group ( P < 0. 05 ). The observation group had lower bleeding rate, shorter exhaust time, bedtime and shorter hospital stay compared with the control group. The level of E2 in observation group at 3 months after operation was lower than that in control group and 25 (OH) D was higher than that in control group. The total effective rate in the observation group (87. 5%) was higher than that in the control group (70. 0%), The differences were statistically significant (all P <0. 05). Difference in the positive rate of incision edge between the two groups was statistically significant (P > 0. 05 ). Conclusions Laparoscopic surgery is helpful to reduce the bedtime and hospital stay and incidence of complications of patients with early cervical cancer. With high short-term efficacy and safety, it is of important therapeutic value.