观察不孕症患者性激素水平检测的临床价值

Observation of the clinical value of detection of sex hormone levels in infertile patients

目的观察不孕症患者性激素水平检测的临床价值。方法随机选取2015年5月至2017年5月深圳市罗湖区妇幼保健院诊治的60例不孕症患者为研究对象,依据疾病类型将其分为原发性不孕组和继发性不孕组,每组30例患者;同时,选取来深圳市罗湖区妇幼保健院进行健康体检的30例已育女性作为正常对照组:对三组人员的血清性激素6项指标水平进行统计分析。结果原发性不孕组、继发性不孕组患者的血清促卵泡生成素(FSH)、黄体生成素(LH)、孕酮(P)、睾酮(T)和雌二醇(E2)水平均显著低于正常对照组(均P<0.05),血清泌乳素(PRL)水平均高于正常对照组(P<0.05);同时,原发性不孕组患者的血清PRL水平显著高于继发性不孕组(P<0.05)。卵泡期,原发性不孕组、继发性不孕组患者的血清FSH、T和E2水平均显著低于正常对照组成员(均P<0.05),血清PRL、P水平均显著高于正常对照组成员(均P<0.05)。排卵期,原发性不孕组、继发性不孕组患者的血清LH、FSH、T、P和E2水平均显著低于正常对照组(均P<0.05)。黄体期,原发性不孕组、继发性不孕组患者的血清LH、PRL水平均显著高于正常对照组患者(均P<0.05),血清P水平均显著低于正常对照组患者(P<0.05)。结论检测不孕症患者性激素水平具有较高的临床价值,能够为临床诊断不孕症提供依据,并有效鉴别诊断原发性不孕与继发性不孕及其所处时期。

Objective To observe the clinical value of the detection of sex hormone levels in infertile patients. Methods 60 infertile patients in Shenzhen Luohu District Maternal and Child Health Hospital from May 2015 to May 2017 were randomly selected and divided into primary infertility group (n =30) and secondary infertility group (n =30) according to the types of disease. Another 30 healthy fertile women received physical examination in Shenzhen Luohu District Maternal and Child Health Hospital were selected as the control group. The levels of 6 serum sex hormone indexes of the three groups were statistically analyzed. Results The serum FSH, LH, P, T and E2 levels of the primary infertility group and secondary infertility group were significantly lower and the serum PRL levels were significantly higher than those of the normal control group ( all P < 0. 05 ). The serum PRL level of the primary infertility group was significantly higher than that of the secondary infertility group ( P < 0. 05 ). During the follicular phase, the serum FSH, T and E2 levels of the primary infertility group and secondary infertility group were significantly lower and the serum PRL, P levels were significantly higher than those of the normal control group ( all P < 0. 05 ). During the ovulation phase, the serum LH, FSH P, T, and E2 levels of the primary infertility group and secondary infertility group were significantly lower than those of the control group ( all P < 0. 05 ). During the luteal phase, the serum LH and PRL levels of the primary infertility and secondary infertility group were significantly high- er( all P < 0. 05 ) and the serum P levels were significantly lower than those of the control group (all P < 0. 05 ). Conclusions It is of high clinical value to detect the sex hormone levels of patients with infertility, which can provide effective basis for the clinical diagnosis of infertility including the differential diagnosis of primary infertility and secondary infertility and its period.