摘要
本研究采用光学微流变仪对不同浓度膀胱脱细胞基质(BAM)预凝胶水溶液的动态成胶过程进行考察。结果表明,在BAM水凝胶成胶过程中,颗粒均方位移(MSD)曲线均出现平台区,且流动因子(FI)逐渐减小,即发生溶胶-凝胶转变;随着BAM浓度的增加,MSD曲线平台区高度降低且向右移动,宏观黏度因子(MVI)和弹性因子(EI)逐渐增大,网格尺寸(ξ)减小,即凝胶粘弹性增强。本研究为组织工程应用中原位注射BAM水凝胶提供了流变学参考。
In this study, the microrheological properties of bladder acellular matrix (BAM) pre-gel solutions with different mass concentrations were investigated during gelation by optical microrheometer. Results showed that the mean square displacement (MSD) of all BAM pre-gel solution generated a plateau region and the fluidity index (FI) gradually decreased. Furthermore, as the BAM concentration increased, the platform height of MSD curves decreased, and the curves shifted to right. The macroscopic viscosity index (MVI), elasticity index (EI) gradually increased, while the mesh size decreased, which indicated that viscoelasticity of BAM hydrogel increased. This study provided a rheological reference for the in situ injection of BAM hydrogels in tissue engineering.
作者
刘文景
范苏娜
张慧慧
邵惠丽
宋鲁杰
黄建文
张耀鹏
Liu Wenjing;Fan Suna;Zhang Huihui;Shao Huili;Song Lujie;Huang Jianwen;Zhang Yaopeng(State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,College of Materials Science and Engineering,Donghua University,Shanghai 201620,China;Department of Urology,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Shanghai 200233,China)
出处
《合成技术及应用》
2019年第1期11-15,共5页
Synthetic Technology & Application
基金
国家重点研发计划
2018YFC1105802
国家自然科学基金
21674018
81600524
关键词
膀胱脱细胞基质
水凝胶
微流变性能
溶胶-凝胶转变
bladder acellular matrix
hydrogel
microrheological properties
sol-gel transition
