肿瘤相关巨噬细胞和巨噬细胞清除受体1对前列腺癌预后的预测价值:系统综述和Meta分析

Prognosticrole of tumour-associated macrophages and macrophage scavenger receptor 1in prostate cancer:a systematic review and meta-analysis

目的本研究旨在通过系统综述及Meta分析研究肿瘤相关巨噬细胞(TAMs)在前列腺癌预后分析中的作用。方法我们在PubMed、Embase和the Cochrane Library三大主要数据库对TAMs及巨噬细胞清除受体1(MSR1)与前列腺癌预后相关文献进行系统检索,筛选并提取相关数据后,合并患者生存数据的HR及对应的95%CI并进行Meta分析。结果分析结果显示TAMs密度与前列腺癌患者总生存期呈负相关性(HR=1.57,95%CI:1.15～1.98),但与患者的生化复发(HR=1.01,95%CI:0.98～1.04)和无复发生存期(HR=1.03,95%CI:0.05～2.01)无明显相关性。与此相反,前列腺癌组织MSR1的表达上调,与患者无复发生存期呈显著正相关(HR=3.26,95%CI:1.22～5.29)。结论 Meta分析结果显示更高密度的TAMs与前列腺癌患者的更短总生存期显著相关,但是与患者的生化复发率和无复发生存期无显著相关性。

Objective To study the role of tumour-associated macrophages and the expression of macrophage scavenger receptor 1 (MSR1) in prostate cancer progression by systematic review and meta-analysis . MethodsWe conducted a systematic search in PubMed, Embase and the Cochrane Library for relevant studies.A meta-analysis was performed to evaluate the prognostic value of tumour associated macrophages and MSR1 by pooled the hazard ratio and 95% confidence intervals of the survival data. ResultsThe results showed that patients with higher density of tumour associated macrophages had shorter overall survival ( HR =1.57, 95% CI :1.15-1.98), but no significant correlation with biochemical recurrence ( HR =1.01, 95% CI :0.98-1.04) or recurrence-free survival ( HR =1.03, 95% CI :0.05-2.01). By contrast, elevated expression of MSR1 was significantly associated with better recurrence-free survival ( HR =3.26, 95% CI :1.22-5.29). ConclusionsHigher density of tumour-associated macrophages is related to shorter overall survival in patients with prostate cancer, but cannot affect biochemical recurrence or recurrence-free survival.