期刊文献+

甘丙肽与人类代谢综合征关系的研究进展

Research progress in the relationship between galanin and human metabolic syndrome
下载PDF
导出
摘要 人类代谢综合征是目前临床常见病,目前人类代谢综合征的发病机制虽然尚未明确,但其均与遗传、免疫、环境等各种因素有关。甘丙肽能够拮抗炎症的发生发展。甘丙肽与胰岛素抵抗、慢性炎症过程之间存在内在联系。同时甘丙肽还可以通过抗炎和调节血糖平衡,影响胰岛素抵抗发生发展。 At present,human metabolic syndrome is a common disease.The pathogenesis of human metabolic syndrome is not clear yet,but it is related to heredity,immunity,environment and so on.There is intrinsic relationship between galanin and insulin resistance and chronic inflammatory process.At the same time it can also regulate glucose homeostasis by galanin and anti-inflammatory effects of the development of insulin resistance.
作者 郭丽丽 GUO Li-li(School of Physical Education,Chuzhou University,Chuzhou,Anhui 239000)
出处 《赣南医学院学报》 2019年第2期213-216,共4页 JOURNAL OF GANNAN MEDICAL UNIVERSITY
基金 安徽省教育厅自然科学重点项目(项目编号:KJ2017A427) 滁州学院校级立项课题(编号2014sk09) 安徽省教育厅2018高校骨干教师访学研究项目(编号:gxgnfx2018048)
关键词 代谢综合征 胰岛素抵抗 甘丙肽 炎症因子 Metabolic syndrome Insulin resistance Galanin Inflammatory factor
  • 相关文献

参考文献1

二级参考文献20

  • 1Tatemoto K, Rokaeus A, Jornvall H, et al. Galanin-a novel biologically active peptide from porcine intestine EJ] FEBS Lett, 1983, 164(1): 124 128.
  • 2Fang P, Yu M, Shi M Y, et ai. Galanin peptide family as a modulating target for contribution to metabolic syndrome [J]. Gen Comp Endocrinol, 2012, 179(1) : 115-120.
  • 3Ahr6n B, Pacini G, Wynick D, et al. Loss-of-function mutation of the galanin gene is associated with perturbed islet function in mice [J]. Endocrinology, 2004, 145(7) : 3190-3196.
  • 4Poritsanos N J, Mizuno T M, Lautatzis M E, et al. Chronic increase of circulating galanin levels induces obesity and marked alterations in lipid metabolism similar to metabolic syndrome [J]. Int J Obes (Lond), 2009, 33 (12): 1381-1389.
  • 5Guo L, Shi M, Zhang L, et al. Galanin antagonist increases insulin resistance by reducing glucose transporter 4 effect in adipocytes of rats EJ]. Gen Comp Endocrinol, 2011, 173(1): 159-163.
  • 6Liang Y, Sheng S, Fang P, et al. Exercise-induced galanin release facilitated GLUT4 translocation in adipocytes of type 2 diabetic rats EJ]. Pharmacol Biochem behav, 2012, 100(3) : 554-559.
  • 7Zhang Z, Sheng S, Guo L, et al. Intracerebroventricular administration of galanin antagonist sustains insulin resist- ance in adipocytes of type 2 diabetic trained rats FJ]. Mol Cell Endocrinol, 2012, 361(1/2) : 213-218.
  • 8Sollenberg U E, Runesson J, Sillard R, et al. Binding of chimeric peptides M617 and M871 to galanin receptor Type 3 reveals characteristics of galaninreceptor-ligand interaction FJ]. Int J Pept Res Ther, 2010, 16(3): 17-22.
  • 9Kraegen E W, James D E, Bennett S P, et al. In vivo insulin sensitivity in the rat determined by euglycemic clamp I-J:. AmJ Physiol, 1983, 245(1): 1-7.
  • 10Legakis I N. The role of galanin in metabolic disorders leading to type 2 diabetes mellitus [J:. Drug News Per- spect, 2005, 18(3): 173-177.

共引文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部