摘要
Objectives:To evaluate the efficacy of 18F-FDG-PET/CT in detection toward the vulnerabilities of carotid plaque and review systematically best evidence to prevent acute stroke from unstable carotid plaque.Methods:A search was conducted on Medline(PubMed),Web of science,Cochrane and WHIC using the search terms‘PET/CT’AND‘18F-FDG’AND‘fluorodeoxyglucose’AND‘carotid plaque’,from 2013/01/01 to now.Two authors will independently extract data following the study characteristics,eligibility criteria,interventions,outcome measurements,duration,adverse events,results and the type of needle used.All searched articles were inserted into in EndNote software that can automatically save,manage,and delete duplicate documents.Results:There were 3 articles included in the systematic review finally and form the study population analysis.The total 89 patients(64 males and 25 females)identified from the included studies.The mean 18F-FDG injected dose was 4.58 MBq/kg.The last three articles have demonstrated that 18F-FDG can accurately identify the stability of carotid plaques and can accurately locate and identify high-inflammation areas by histological analysis.Conclusions:18F-FDG-PET/CT is very efficient and practical for the identification of carotid vulnerable plaques.TBR(max and mean values)as a parameter for identifying inflammatory plaques is more reliable than SUV.
目的:评价18F-FDG-PET/CT对颈动脉斑块易损部位的检测效果,系统回顾预防急性卒中发生颈动脉不稳定斑块的最佳证据。方法:使用搜索词‘PET/CT’AND‘18F-FDG’AND‘fluorodeoxyglucose’AND‘carotidplaque’在Medline(PubMed),Web of science,Cochrane和WHIC数据库上进行检索,检索时间限定为2013/01/01到现在。两位作者将根据研究特点、合格标准、干预措施、结果评估、持续时间、不良事件等独立提取数据。所有搜索到的文章都被插入EndNote软件中,该软件可以自动保存、管理和删除重复的文档。结果:最后系统回顾纳入3篇文章。从纳入的研究中确定了89例患者(64名男性和25名女性)。18F-FDG平均注射剂量为4.58MBq/kg。这三篇文章证明18F-FDG可以准确识别颈动脉斑块的稳定性,通过组织学分析可以准确定位和识别高炎症区域。结论:18F-FDG-PET/CT对颈动脉易损斑块的识别非常有效和实用。TBR(最大值和平均值)作为炎症斑块识别的参数比SUV更可靠。
