直肠癌XRCC1和XRCC4表达与术前放化疗敏感性研究

Study on the expression of XRCC1 and XRCC4 in rectal cancer and the sensitivity of preoperative radiotherapy and chemotherapy

目的探讨直肠癌组织中XRCC1和XRCC4的表达与术前放化疗敏感性的相关性。方法采用免疫组化方法检测55例行术前放化疗直肠癌组织中XRCC1和XRCC4的表达,通过T分期降期来评估XRCC1和XRCC4的表达与术前放化疗疗效的关系。结果 XRCC1高表达组6例出现T分期降期,低表达组26例出现T分期降期。XRCC4高表达组5例出现T分期降期,低表达组27例出现T分期降期。XRCC1和XRCC4表达与T分期降期差异有统计学意义(P<0.05)。Spearman相关性分析显示XRCC1和XRCC4表达与术前放化疗疗效呈负相关(分别为r=-0.432,P=0.002;r=-0.350,P=0.009)。结论直肠癌组织中XRCC1和XRCC4表达与术前放化疗疗效相关,可作为判断对放化疗敏感性的参考指标。

Objective To investigate the relationship between the expression of XRCC1 and XRCC4 in rectal cancer and the sensitivity of preoperative chemotherapy and radiotherapy. Methods Immunohistochemical method was used to detect the expression of XRCC1 and XRCC4 in 55 cases of rectal cancer tissues undergoing preoperative radiotherapy and chemotherapy. The relationship between the expression of XRCC1 and XRCC4 and the efficacy of preoperative chemotherapy and radiotherapy was evaluated by T stage down-staging. Results There were 6 patients in XRCC1 high expression group showing T stage down-staging. In the low expression group, there were 26 patients showing T stage down-staging. In the XRCC4 high expression group, there were 5 patients showing T stage down-staging. In the low expression group, there were 27 patients showing T stage down-staging. There was a statistically significant difference between XRCC1 and XRCC4 expression and T stage down-staging (P<0.05). Spearman correlation analysis showed that XRCC1 and XRCC4 expression were negatively correlated with preoperative chemotherapy and radiotherapy (r=-0.432, P=0.002;r=-0.350, P=0.009, respectively). Conclusion The expression of XRCC1 and XRCC4 in rectal cancer is related to the efficacy of preoperative chemotherapy and radiotherapy, and can be used as a reference indicator for judging the sensitivity to radiotherapy and chemotherapy.