甘精胰岛素和阿卡波糖联合对2型糖尿病的疗效及颈部斑块状况的影响

Effect of combination of insulin glargine and acarbose on type 2 diabetes mellitus and cervical plaque status

目的研究甘精胰岛素和阿卡波糖联合对2型糖尿病的疗效及颈部斑块状况的影响。方法选择我院自2015年11月～2018年5月收治的91例2型糖尿病患者进行研究,按照随机数字表法,所有患者随机分为对照组42例和观察组49例,对照组给予阿卡波糖常规治疗,观察组给予甘精胰岛素和阿卡波糖联合治疗,两组均持续治疗1个月疗程。治疗前后比较两组患者空腹血糖、餐后2 h血糖和糖化血红蛋白表达水平,并通过颈部血管超声检查患者颈部血管斑块大小变化情况。结果治疗1个月后,在空腹血糖、餐后2 h血糖和糖化血红蛋白水平表达方面,观察组患者结果与对照组相比有明显差异(P<0.05);观察组患者在颈部斑块变化方面明显小于对照组,差异具有统计学意义(P<0.05);两组治疗后不良反应发生率差异无统计学意义(P>0.05)。结论甘精胰岛素和阿卡波糖联合对2型糖尿病患者进行治疗,可降低血糖水平,减小颈部血管斑块,临床疗效较好,值得应用推广。

Objective To study the effect of combination of insulin glargine and acarbose on type 2 diabetes mellitus and cervical plaque status. Methods A total of 91 patients with type 2 diabetes admitted to our hospital from November 2015 to May 2018 were enrolled. According to the random number table method, all patients were randomly divided into the control group(42 cases) and the observation group(49 cases). The control group was given routine treatment with acarbose, and the observation group was given combination therapy with insulin glargine and acarbose. Both groups were treated for 1 month. The fasting blood glucose, postprandial 2 h blood glucose and glycosylated hemoglobin expression levels were compared before and after treatment, and the changes of cervical vascular plaque size were examined by cervical vascular ultrasonography. Results After 1 month of treatment, the results of fasting blood glucose, postprandial 2h blood glucose and glycosylated hemoglobin levels were significantly different between the observation group and the control group(P<0.05). The sizes of cervical plaque in the observation group was significantly smaller than those in the control group, and the difference was statistically significant(P<0.05). There was no significant difference in the incidence of adverse reactions after treatment(P>0.05). Conclusion The combination of insulin glargine and acarbose in the treatment of type 2 diabetes can lower blood glucose levels, reduce cervical vascular plaque size, and has a good clinical effect, which is worthy of application.