PEM/DDP对晚期非鳞肺癌患者心理状况及睡眠质量的影响及参麦注射液的作用

Effect of PEM/DDP on psychological status and sleep quality of patients with advanced non-squamous lung cancer and the effect of Shenmai injection

目的探讨PEM/DDP对晚期非鳞肺癌患者心理状况及睡眠质量的影响及参麦注射液的作用。方法选取2009年7月～2017年12月收治的晚期(Ⅲ～Ⅳ期)非鳞肺癌患者60例,按照治疗方法的不同随机分为研究组和对照组两组,各30例,两组患者在治疗后均接受常规生物学指标检查。研究组采用PEM/DDP化疗联合参麦注射液进行治疗,每次化疗第0～7天接受参麦注射液静脉滴注;对照组单独使用PEM/DDP化疗,每3周重复化疗,观察两组患者的治疗方法对心理状况以及睡眠质量的影响及对两组患者的不良反应。结果研究组患者的心理状况、睡眠质量、生活质量等评分显著优于对照组(P<0.05)。对照组焦虑自评量表(SAS)以及抑郁自评量表(SDS)评分分别为(35.3±3.2)分、(35.3±3.2)分,研究组SAS以及SDS评分分别为(23.2±3.1)分、(23.2±3.1)分;对照组和研究组在治疗8周后PSQI评分分别为(8.2±1.3)分、(6.9±1.1)分。研究组不良反应发生率显著低于对照组(P<0.05)。结论 PEM/DDP化疗联合参麦注射液治疗晚期非鳞肺癌患者的临床疗效显著,对患者的心理状况、睡眠质量有改善作用,可提高晚期非鳞肺癌患者的生活质量,值得推广与应用。

Objective To explore the effect of PEM/DDP on the psychological status and sleep quality of patients with advanced non-squamous lung cancer and the effect of Shenmai injection. Methods 60 patients with advanced(Ⅲ-IV) non-squamous lung cancer from July 2009 to December 2017 were randomLy divided into two groups including the study group and the control group according to the treatment method, with 30 patients in each group. Two groups underwent routine biological indicators examination. The study group was treated with PEM/DDP chemotherapy combined with Shenmai injection. The method was to receive intravenous infusion of Shenmai injection on the 0th-7th day of each chemotherapy, and the control group was treated with PEM/DDP chemotherapy alone every three weeks. The effects of treatment methods on psychological status and sleep quality were compared between the two groups, and the adverse reactions of the two groups were compared. Results The psychological status, sleep quality,quality of life and other scores of the two groups were compared. The scores of psychological status, sleep quality and quality of life of the study group were also significantly better than those of the control group(P<0.05). The self-rating anxiety scale (SAS) and the self-rating depression scale (SDS) scores of the control group were (35.3±3.2) and(35.3±3.2).And the scores of SAS and SDS of the study group were(23.2±3.1),(23.2±3.1) respectively. The PSQI scores of the control group and the study group were (8.2±1.3) and (6.9±1.1) after 8 weeks of treatment. The incidence of adverse reactions bewteen the two groups was compared. The incidence of adverse reactions in the study group was significantly lower than that in the control group(P<0.05). Conclusion PEM/DDP chemotherapy combined with Shenmai injection is effective in the treatment of patients with advanced non-squamous lung cancer, which can improve the psychological status and sleep quality, and improved the quality of life of patients with advanced non-squamous lung cancer, and is worthy of promotion and application.