儿童抗NMDAR脑炎的诊治研究进展

Research advances in pediatric anti-NMDAR encephalitis

抗N-甲基-D-天冬氨酸受体(N-methyl-D-aspartate receptor,NMDAR)脑炎是儿童最常见的自身免疫性脑炎之一,具有潜在的致死性。近年来,关于此病的报道逐渐增多,并提出早期给予免疫治疗可改善预后。由于儿童抗NMDAR脑炎的临床表现有其非典型性,故早期识别、诊断及治疗尤为重要。本文根据最新的研究,就儿童抗NMDAR脑炎的临床表现和实验室检查,免疫治疗及预后作一综述,以期为医生及研究者们提供参考。

Anti N-methyl-D-aspartate receptor(Anti-NMDAR) encephalitis is one of the most common autoimmune encephalitis in children. It may cause death. In recent years, an increasing number of the anti-NMDAR encephalitis cases have been reported, and it is suggested that early immunotherapy can get better prognosis. As the clinical manifestations of children with anti-NMDAR encephalitis are atypical, so early diagnosis and early treatment are particularly important. In this paper, the clinical symptoms, laboratory examinations, immunotherapy and prognosis of children with anti-NMDAR encephalitis are reviewed in order to provide reference for doctors and researchers.