二甲双胍治疗胰岛素抵抗的复发性流产患者的临床效果

Clinical effect of Metformin in the treatment of insulin resistance patients with recurrent spontaneous abortion

目的观察二甲双胍治疗胰岛素抵抗(IR)的复发性流产(RSA)的临床效果。方法选取2016年1月～2018年1月我院收治的100例IR的RSA患者,根据治疗方案将其分为对照组(48例)与观察组(52例)。对照组患者妊娠前口服二甲双胍片,妊娠后停用二甲双胍,应用黄体酮安胎治疗;观察组患者在对照组的基础上,妊娠后仍继续口服二甲双胍片治疗。观察两组患者治疗前后的IR指数(HOMA-IR)变化,记录两组的妊娠结局及不良反应发生情况。结果观察组患者治疗后的HOMA-IR显著低于对照组,差异有统计学意义(P<0.05)。观察组患者的流产率及不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论二甲双胍治疗IR的RSA的临床效果良好且安全性较好,可有效改善患者的IR情况,降低流产率。

Objective To observe the clinical effect of Metformin in the treatment of recurrent spontaneous abortion (RSA) combined with insulin resistance (IR). Methods A total of 100 IR patients with RSA in our hospital from January 2016 to January 2018 were selected. According to treatment options,they were divided into the control group (48 cases) and the observation group (52 cases). The control group received oral Metformin Tablets before pregnancy,stopping Metformin after pregnancy,and Progesterone was used for treatment. The observation group continued to take Metformin Tablets after pregnancy on the basis of the control group. The changes of homeostasis model of assessment for insulin resistence index (HOMA-IR) before and after treatment were observed between the two groups. The pregnancy outcomes and adverse reactions of the two groups were also recorded. Results After treatment,the HOMA-IR of the observation group was significantly lower than that of the control group,and the difference was statistically significant (P<0.05). The incidence rate of abortion and the total incidence rate of adverse reactions in the observation group were lower than those in the control group,and the differences were statistically significant (P<0.05). Conclusion Metformin in the treatment of IR patients with RSA has good clinical effect and good safety,which can effectively improve the patients' IR and reduce the abortion rate.