双酯型丙烯腈类化合物的合成及杀螨活性

Synthesis and Acaricidal Activity of Diester Acrylonitrile Compounds

以杀螨剂腈吡螨酯为先导化合物,将3-[4-(叔丁基)苯基]-3-氰基-2-羟基丙烯酸乙酯与不同酰氯化合物进行酯化反应,合成了5个具有杀螨活性的新型双酯型丙烯腈类化合物,其化学结构经过~1H NMR确证。室内生物活性测试结果显示:目标化合物TM-3和TM-5具有优异的杀螨活性,化合物TM-5在质量浓度为10 mg/L时,对朱砂叶螨螨卵的致死率达到93%,具有进一步的研究开发价值。

The diester-type acrylonitrile compounds with acaricidal activity were synthesized by using acaricide cyenopyrafen as a lead compound. Five novel diester acrylonitrile compounds were obtained by the reaction of ethyl 3-[4-(tert-butyl) phenyl]-3-cyano-2-hydroxyacrylate with different acyl chlorides. Their chemical structures were confirmed by 1H NMR. Indoor bioassay showed that the target compounds TM-3 and TM-5 had excellent acaricidal activities. The compound TM-5 exhibited a lethal rate of 93% against T. cinnabarinus at the concentration of 10 mg/L, which was valuable for further research.