乳癖散结颗粒联合化疗治疗乳腺癌术后患者的效果及对其生活质量的影响

Effect of Rupi Sanjie granules combined with chemotherapy on the clinical efficacy and quality of life in breast cancer patients after surgery

目的探讨乳腺癌术后患者接受乳癖散结颗粒联合化疗对其肿瘤标志物水平、免疫功能指标水平及生活质量的影响。方法选取98例早期乳腺癌患者,根据术后治疗方案分为观察组(术后辅助化疗+乳癖散结颗粒治疗)与对照组(术后辅助化疗),每组49例。比较两组患者治疗前后的免疫功能指标水平、肿瘤标志物水平和治疗后不良反应的发生情况,采用健康调查简表(SF-36)评估患者的生活质量。结果治疗前,两组患者的癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原153(CA153)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、CD4^+、CD8^+、CD69水平及SF-36各条目评分比较,差异均无统计学意义(P﹥0.05)。治疗后,观察组患者的CEA、CA125、CA153水平均明显低于对照组(P﹤0.01),两组患者的上述肿瘤标志物水平均低于本组治疗前(P﹤0.05)。治疗后,观察组患者的IgA、IgG、IgM、CD4^+、CD8^+、CD69水平均明显高于对照组(P﹤0.01),观察组患者的上述免疫功能指标水平均高于治疗前(P﹤0.05)。观察组患者不良反应的总发生率为51.0%,低于对照组的73.5%(P﹤0.05)。治疗后,观察组患者的各项生活质量指标评分均明显高于对照组(P﹤0.01),两组患者的各项生活质量评分均高于本组治疗前(P﹤0.05)。结论早期乳腺癌患者术后辅以化疗联合乳癖散结颗粒治疗,可以改善患者免疫功能,降低肿瘤标志物水平,且不良反应少,有助于更好地改善患者的生活质量。

Objective To investigate the clinical effect of Rupi Sanjie granules combined with chemotherapy in the treatment of breast cancer, and to observe the effect on postoperative tumor markers, immune function and quality of life. Method Retrospective analysis for 98 cases of early breast cancer was performed to review the clinical data, all patients were stratified as study group (postoperative adjuvant chemotherapy ^+ Rupi Sanjie granules) and control group (postoperative adjuvant chemotherapy), with 49 cases in each. The levels of immune function markers and tumor markers, as well as adverse reactions after treatment were compared between the two groups. The MOS 36 item short form health survey (SF-36) was used to evaluate the quality of life of these patients before and after treatment. Result Before treatment, there was no significant difference in the levels of carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), carbohydrate antigen 153 (CA153), immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), CD4^+, CD8^+, CD69, and social function (SF), physiological function (PF), emotional role (RE), physical role (RP), bodily pain (BP), vitality (VT), general health (GH), mental health (MH) scores between the two groups (P>0.05). The levels of CEA, CA125 and CA153 in study group were significantly lower than those in the control group after treatment (P< 0.01);and the levels of them in the two groups were significantly decreased after treatment (P<0.05). In study group, the IgA, IgG, IgM, CD4^+, CD8^+, and CD69 levels were significantly higher than those in the control group (P<0.01) after treatment, and were also higher than those before treatment in study group (P<0.05). The overall incidence of adverse reactions in study group was 51.0%, and was lower than that in control group at 73.5%(P<0.05). The quality of life scores of study group were significantly higher than those of the control group (P<0.01), and were both improved after treatment in the two groups (P<0.05). Conclusion For early breast cancer, postoperative chemotherapy combined with Rupi Sanjie granules is effective in improving the patients’immune function, lowering tumor marker levels, with less adverse reactions, and thus is helpful to improve the quality of life for these patients.