骨相关性浆细胞瘤的临床特征及其影响因素分析

Clinical features of bone-related plasmacytoma and analysis of the influence factors

目的分析骨相关性浆细胞瘤(BRP)的临床特征及其影响因素。方法收集229例多发性骨髓瘤(MM)患者的临床资料,包括基本临床特征、临床检验检查结果。根据影像学检查结果将患者分为BRP组(n=40)和普通MM组(n=189)。分析BRP组和普通MM组患者的临床特征,以及MM患者发生BRP的影响因素。结果BRP组和普通MM组患者的Durie-Salmon(DS)分期和国际分期体系(ISS)分期比较,差异均有统计学意义(P﹤0.05)。普通MM组和BRP组患者的β-胶原降解产物(β-CTX)、红细胞沉降率(ESR)、血尿素氮(BUN)、肌酐(Cr)、尿酸(UA)水平比较,差异均有统计学意义(P﹤0.05)。多因素Logistic回归分析结果显示,β-CTX升高是MM患者发生BRP的独立保护因素(P﹤0.05,OR=0.050)。结论β-CTX升高可作为MM患者发生BRP的独立保护因素。

Objective To explore the clinical features of bone-related plasmacytoma (BRP) and to investigate the influence factors. Method The clinical data of 229 patients with multiple myeloma (MM) were collected, including general data and clinical laboratory test results. According to the characteristics of imaging, subjects were divided as BRP group (n=40) and common MM group (n=189). The clinical features of BRP group and common MM group patients were analyzed, besides, the factors influencing the occurrence of BRP in MM patients were investigated. Result The Durie- Salmon (DS) stage and International Staging System (ISS) stage in BRP group and common MM group differed significantly (P<0.05). Evident differences were noted regarding the β-collagen degradation product (β-CTX), erythrocyte sedimentation rate (ESR), blood urea nitrogen (BUN), creatinine (Cr), and uric acid (UA) level between common MM group and BRP group patients, showing statistically significant differences (P<0.05). Multivariate logistic regression analysis showed that incresed β-CTX was an independent protective factor in the development of BRP among MM patients (OR= 0.050, P<0.05). Conclusion Increased β-CTX can be an independent protective factor for the occurrence of BRP in MM patients.