多潘立酮联合奥美拉唑对喉咽反流性疾病治疗的影响

Effect of domperidone combined with omeprazole on the treatment of laryngeal reflux disease

目的探讨多潘立酮联合奥美拉唑对喉咽反流性疾病治疗的影响。方法选取我院2013年8月～2014年8月接收的86例喉咽反流性患者作为研究对象,采用抽签法分为观察组和对照组,各43例。对照组单纯使用多潘立酮进行治疗,观察组在对照组基础上加用奥美拉唑进行治疗,治疗时间均为4周,观察比较两组患者的临床疗效、唾液胃蛋白酶在1、2、3、4周转阴率、不良反应发生情况。结果观察组患者临床总有效率为93.02%,显著高于对照组,差异具有统计学意义(P <0.05);观察组患者唾液胃蛋白酶在1、2、3、4周转阴率分别为69.77%、83.72%、93.02%、95.35%,均显著高于对照组(P <0.05);观察组患者不良反应发生率显著低于对照组(P <0.05)。结论采用多潘立酮联合奥美拉唑治疗喉咽反流性疾病临床效果显著,有效改善唾液胃蛋白酶转阴情况,减少不良反应的发生,值得在临床上推广。

Objective To explore the effect of domperidone combined with omeprazole on the treatment of laryngopharyngeal reflux disease. Methods 86 patients of laryngopharyngeal reflux patients received in our hospital from August 2013 to August 2014 were selected and divided into observation group and control group in random law method, with 43 cases in each group. Patients in the control group were treated only with domperidone, while patients in the observation group were further treated with omeprazole. The clinical efficacy, turnover rate of saliva pepsin in 1, 2, 3 and 4 weeks, and the incidence of adverse reactions were observed and compared between the two groups.Results The total clinical efficiency of the observation group was 93.02%, significantly higher than that of the control group, and the difference was statistically significant(P < 0.05). The positive rate of salivary pepsin in 1, 2, 3, and4 weeks were 69.77%, 83.72%, 93.02% and 95.35%,respectively in the observation group, which were significantly higher than the control group(P < 0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P < 0.05). Conclusion The use of domperidone combined with omeprazole in the treatment of laryngopharyngeal reflux disease has a significant clinical effect, which can effectively improve the negative conversion of saliva pepsin and reduce the occurrence of adverse reactions. Therefore, it is worth promoting in clinical practice.